Herpesvirdae Flashcards Preview

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Flashcards in Herpesvirdae Deck (25):
1

Sub Family: Alpha

HSV-1 = HHV-1
HSV-2 = HHV-2
VZV = HHV-3

2

Sub Family: Beta

HCMV = HHV-5
Roseolovirus = HHV-6
Roseolovirus = HHV-7

3

Sub Family: Gamma

Lymphocryptovirus = HHV-4 = EBV
Rhadinovirus = HHV8 = KSHV

4

Alpha subfamily growth cycle is ____ and remains latent in ______

Short
Neurons

5

Beta subfamily growth cycle is ____ and remains latent in ______

Long
Glands, Kidney, Macrophages

6

Gamma subfamily growth cycle is ____ and remains latent in ______

Variable
Lymphoid Tissue

7

Structure of Herpesvirdae

Icosahedral capsid, surrounded by a TEGUMENT and wrapped in lipid rich envelope
Linear DNA is circularized in the infected cell

8

Latency

reversibly nonproductive infection of a cell by replication-competent virus

9

Acyclovir works by _____ and is used for _____

acting as an analog for guanosine (chain terminator). it starts as a prodrug that is cleaved by VIRAL thymidine kinase.

Use for HSV-1 and 2, NOT effective against CMV

10

Ganciclovir works by _____ and is used for _____

Acting as a guanosine analog (chain terminator) NOTE: more susceptible to phosphorylation by host cell

CMV! (mostly in AIDS patients)

11

Foscarnet Sodium works by _____ and is used for _____

Analog of phosphate that inhibits vial DNA polymerase by interacting with pyrophosphate binding sites NOTE penetrates CNS and eyes

Acyclovir-resistant HSV-1 and 2
Gancyclovir-resistant CMV

12

Cidofovir works by _____ and is used for _____

Nucleotide analog NOTE: unlike acyclovir, the prodrug is phosphorylated by host cell TK

CMV especially in immunocompromised

13

Acyclovir can be given ___ with the following side effects ______

PO, IV, topical

Generally well tolerated but can include renal insufficiency, nausea, burning at site of application NOTE: interacts with probenecid

14

Ganciclovir can be given ___ with the following side effects ______

Parentarally

Common: bone marrow suppression
Occasional: CNS toxicity, Rash, GI tolerance, anemia
Rare: coma, hepatotoxicity

15

Foscarnet Sodium can be given ___ with the following side effects ______

via IV

Common: Nephrotoxitiy, electrolyte imblanace
Occasional: parasthesias, penile ulcers, GI intolerance
Rare: CNS toxicity

16

Cidofovir can be given ___ with the following side effects ______

via IV (w/ probenecid)

Nephrotoxicity

17

VZV mode of transmission

Inhalation of respiratory secretions

18

HSV-1 mode of transmission

Shed from active lesions and possible some during asymptomatic recurrence
Contracted through skin and mouth lesions
Or via respiratory secretions/saliva

Cases of encephalitis are contracted by infection of the olfactory nerve

19

HSV-2 mode of transmission

Sexual Contact

20

HHV-6 and 7 mode of transmission

Considered part of natural viral flora. Most children are infected by age 3 via parents kisses

21

CMV mode of transmission

Close contact, but also less commonly through breast milk, blood transfusions and sexual contact

22

EBV mode of transmission

Spread by saliva

23

KSHV mode of transmission

Not clear!

24

EBV causes what cancers

Burkitt's lymphoma
Nasopharyngeal Carcinoma
CNS Lymphomas
Leiomyosarcomas in AIDS patients
Hodgkin's disease

25

KSHV causes what cancer

Kaposi's Sarcoma