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Flashcards in Hippo 2 Deck (12):
1

CAMKII phosphorylates ______
causing prolonged activation of CAMKII that can last for days.

itself

2

↑ activity of
CAMKII elicits changes --> larger EPSP, including:

incorporation of AMPA receptors in the postsynaptic plasma membrane

phosphorylation of AMPA--> more responsive to the glutamate.

3

"Longer" term changes

"New neurons" in dentate
involvement in learning not well understood
?

4

Alzheimer’s disease plaques

Amyloid Beta

5

Amyloid Precursor

Can be cut into alpha or beta
Beta is made by Gamma or Beta proteases
AB--> Plaque

6

Aβ deposition in
humans show a failure to
maintain:

LTP in the hippocampus

7

Klüver-Bucy syndrome.

a syndrome resulting from bilateral lesions of the anterior temporal lobe- including amygdaloid nucleus

may present with hyperphagia, hypersexuality, hyperorality, visual agnosia, and docility.

8

Amygdala removed leads to

Fear
Motivation
Attention
Sex drive

9

Conditioned fear is mediated by changes in the neuronal circuits in the _____________

lateral and central nuclei of the amygdala

10

Rats and Amygdala

Tone= no response

Tone + shock--> fear response

tone= fear ( increase of blood pressure and the length of time the animals crouch without moving (freezing))

11

Conditioned flavor aversion (CFA) in mice

mice- eats sugar

Mice- Sugar + Li IP
-- makes the mouse sick

Mice- avoid sugar

*Does work with smell
*Does not work w/ umami

12

Conditioned flavor aversion Mechanism

phosphorylation of NMDA receptor affects its response to stimulation from fibers coming from the amygdala

this is where CFA is transmitted because the amygdala receives information on malaise from the vagus nerve.

*B/c phosphor of NMDA lasts ½ hr, stimulation of amygdala leads to associative learning that causes aversion to the food that was paired with malaise.