Histamine, Serotonin, and the Ergot Alkaloids Flashcards Preview

P Pha T > Histamine, Serotonin, and the Ergot Alkaloids > Flashcards

Flashcards in Histamine, Serotonin, and the Ergot Alkaloids Deck (6):
1

Which histaminergic drug has significant cholinergic effect that it can be used as an adjunct for Parkinson's disease?

Diphenhydramine
SimD: Brompherinamine, cyclizine, dimehydrinate, hydroxyzine, promethazine, cyproheptadine (for serotonin syndrome)
(H1-receptor antagonist)

2

______________ (first-gen H1 receptor antagonist) is hydroxylated to cetirizine (second-gen H1 receptor antagonist).
Cetirizine is noted for fatal arrhythmias from interaction between azoles/erythromycin and terfenadine/astemizole.

Hydroxyzine

3

Drug of choice for acute migraine and cluster headache.
Causes vasoconstriction in cerebral blood vessels.

Sumatriptan (5-HT1D agonist)

4

Used for chemotherapy and postoperative vomiting. Blocks chemoreceptor trigger zone in area postrema and enteric nervous system 5-HT3 receptors

Ondansetron

SimD:
Alosetron (used for irritable bowel disease)
Palonosetron, etc
(5-HT3 receptor antagonist)

5

A vasoselective 5-HT2-receptor antagonist used for migraine and cluster headache.
Antidote is ________________.

Ergotamine

SimD:
Dihydroergotamine
Methysergide (SE: retroperitoneal fibrosis)

nitroprusside

MNEMONIC: Ergotamigraine

6

A uteroselective 5-HT2 receptor antagonist used for postpartum bleeding and migraine

Ergonovine
SimD: Methylergonovine

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