Flashcards in Histamine, Serotonin, and the Ergot Alkaloids Deck (6):
Which histaminergic drug has significant cholinergic effect that it can be used as an adjunct for Parkinson's disease?
SimD: Brompherinamine, cyclizine, dimehydrinate, hydroxyzine, promethazine, cyproheptadine (for serotonin syndrome)
______________ (first-gen H1 receptor antagonist) is hydroxylated to cetirizine (second-gen H1 receptor antagonist).
Cetirizine is noted for fatal arrhythmias from interaction between azoles/erythromycin and terfenadine/astemizole.
Drug of choice for acute migraine and cluster headache.
Causes vasoconstriction in cerebral blood vessels.
Sumatriptan (5-HT1D agonist)
Used for chemotherapy and postoperative vomiting. Blocks chemoreceptor trigger zone in area postrema and enteric nervous system 5-HT3 receptors
Alosetron (used for irritable bowel disease)
(5-HT3 receptor antagonist)
A vasoselective 5-HT2-receptor antagonist used for migraine and cluster headache.
Antidote is ________________.
Methysergide (SE: retroperitoneal fibrosis)