Histology Flashcards
(25 cards)
What processes are included in tissue processing? and examples
Fixation - formaldehyde
Embedding - Wax
Sectioning - cutting
Staining Hhaematoxylin and Eosin
Composition of membrane?
50% Proteins
47% Lipids
3% Carbohydrates
Type of Phospholipid found on the outer layer of the membrane?
Phosphotidly Choline
Two types of Phospholipids found on the inner layer of the membrane?
Phosphotidly Serine
Phosphotidlinistol
What are the two major components of connective tissue?
Cellular and Extracellular
What is the TWO main components of the ECM made up of? with examples.
Ground Substance - Proteoglycans, GAGs, Glycoproteins, water
Fibres - Collagen, Elastin
What is the main function of the ECM?
- Structure and Mechanical support
- Tensile strength
- Creates Micro-environment
What is the main function of Collagen?
Tensile Strength
Where would you find Type III Collagen?
granulation tissue. Dermis of skin
First collagen laid down in tendon healing
Where would you find Type I Collagen?
Dermis of skin, Bone.
Where would you find type II Collagen?
Cartilage
Where would you find Collagen type IV?
Basement membrane
What is the main function of ground substance?
Resist compression
How does ground substance draw water into it?
through the very negatively charged GAGs
Where would you find Hyaluronic Acid?
Synovial Fluid
Where would you find Chondriotin Sulfate?
Cartilage
What is the function of the Basement Membrane?
Provide support
Attachment to the connective tissue
control of nutrients and signals to the epithelial cells
act as barrier for neoplastic epithelial tissue.
What are the main layers of the basement membrane?
Lamina Lucida
Lamina Densa
Lamina Fibrorecticularis
In arteries where would you find the most abduntant nervous supply?
Tunica Media
What kind of junctions does the tunica intima of vessels have?
Tight Junctions
What is the function of the ECM?
Anchors cells
Provides pathway for migrating cells
Sequesters growth factors
Provides residence for roaming macrophages
Stem cell occupation and maintains stem environment
What is the protein assembly of elastin?
Scaffold cross linked fibres
In good-pastures syndrome, what occurs?
auto - Antibodies destroy collagen IV in the basement membrane of the glomerulus and lungs
What collagen is found in fibrocartilage?
Type I and II
