Flashcards in Histopathology 11 - Dermatopathology Deck (28)
Give an example of vesiculobullous inflammation?
What are the aetiological agents of pemphigoid
IgG and C3
They attack the basement membrane and destroy the adhesion molecules
How can you confirm the diagnosis of pemphigoid?
Immunofluorescence of fresh samples to show IgG and C3
What causes pemphigus vulgaris?
Pemphigus antibody attacks proteins that holds cells together in the stratum spinosum, causing "akantholysis", which leads to formation of *suprabasilar bulla*
On which surfaces does psoriasis tend to present?
On which surfaces does eczema tend to present?
What is the appearance of basal cell carcinomas?
Pearly white border
Central area of ulceration
What do pre-cancerous skin cells (Bowen's disease) look like histologically?
Atypical mitotic figures
All within the epidermis
What is the upward spread of melanocytes known as?
When would mitotic figues in the skin not be alarming?
The Breslow thickness is used to stage which skin cancer?
Which common skin cancer does not metastasise?
Basal cell carcinoma
Is diameter or thickness more important for malignant melanoma?
Which patient group is most at risk of pemphigus foliaceus?
The elderly - but it's rare
Which cells of the immune system are most involved in eczema?
T-cell mediated pathology
Eosinophils recruited to sites of inflammation
Where does fluid build in eczema?
Which skin pathology appears as "silvery plaques"?
Which immune-mediated skin condition causes a rapid turnover of keratinocytes?
Which skin condition appears as white lines?
Which skin condition appears as a "pigmented cauliflower"?
Which skin condition forms "keratin horns"?
Describe the appearance of a sebaceous cyst?
Round, smooth surface, central punctum
Which types of invasion is basal cell carcinoma most likely to exhibit?
Perineural or vascular
What is Bowen's disease?
Pre-cancerous stage of basal cell carcinoma
Which type of skin cancer is most likely to become invasive?
Squamous cell carcinoma
What is the fancy name for a mole?
Benign junctional naevus
Which type of skin cancer demonstrates upward migration of melanocytes?