Histopathology 11 - Dermatopathology Flashcards Preview

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Flashcards in Histopathology 11 - Dermatopathology Deck (28)
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1

Give an example of vesiculobullous inflammation?

Bullous pemphigoid

2

What are the aetiological agents of pemphigoid

IgG and C3
They attack the basement membrane and destroy the adhesion molecules

3

How can you confirm the diagnosis of pemphigoid?

Immunofluorescence of fresh samples to show IgG and C3

4

What causes pemphigus vulgaris?

Pemphigus antibody attacks proteins that holds cells together in the stratum spinosum, causing "akantholysis", which leads to formation of *suprabasilar bulla*

5

On which surfaces does psoriasis tend to present?

Extensor

6

On which surfaces does eczema tend to present?

Flexor

7

What is the appearance of basal cell carcinomas?

Pearly white border
Central area of ulceration

8

What do pre-cancerous skin cells (Bowen's disease) look like histologically?

Pleomorphic
Atypical mitotic figures
All within the epidermis

9

What is the upward spread of melanocytes known as?

Pagetoid spread

10

When would mitotic figues in the skin not be alarming?

Pregnancy

11

The Breslow thickness is used to stage which skin cancer?

Malignant melanoma

12

Which common skin cancer does not metastasise?

Basal cell carcinoma

13

Is diameter or thickness more important for malignant melanoma?

Thickness

14

Which patient group is most at risk of pemphigus foliaceus?

The elderly - but it's rare

15

Which cells of the immune system are most involved in eczema?

T-cell mediated pathology
Eosinophils recruited to sites of inflammation

16

Where does fluid build in eczema?

Between keratinocytes

17

Which skin pathology appears as "silvery plaques"?

Psoriasis

18

Which immune-mediated skin condition causes a rapid turnover of keratinocytes?

Psoriasis

19

Which skin condition appears as white lines?

Lichen planus

20

Which skin condition appears as a "pigmented cauliflower"?

Seborrhoeic keratosis

21

Which skin condition forms "keratin horns"?

Seborrhoeic keratosis

22

Describe the appearance of a sebaceous cyst?

Round, smooth surface, central punctum

23

Which types of invasion is basal cell carcinoma most likely to exhibit?

Perineural or vascular

24

What is Bowen's disease?

Pre-cancerous stage of basal cell carcinoma

25

Which type of skin cancer is most likely to become invasive?

Squamous cell carcinoma

26

What is the fancy name for a mole?

Benign junctional naevus

27

Which type of skin cancer demonstrates upward migration of melanocytes?

Malignant melanoma

28

A lump on the upper lip may be due to which type of cancer?

Metastatic renal cell carcinoma

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