PassNaplexNow - NAPLEX review prep > HIV - Brand/Generic > Flashcards

HIV - Brand/Generic Flashcards

(54 cards)

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1
Q

Protease Inhibitors

  • MOA
  • Take w/:
  • Excrete:
  • Sulfa allergy
A
  • Protease enzyme breaks down the protein into function units to be used for final assembly of new virus. Protease inhibitors inhibit this enzyme
  • All take w/ food except Indinavir and Fosamprenavir suspension
  • All excrete the LIVER
  • Sulfa allergy: fosamprenavir, darunavir, tiprinavir
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2
Q

AgenerASE

A

AMprenavir

=> Cha Am dan dan bi erASE ddi

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3
Q

CRIXivan

  • SE
A

INDInavir

  • Kidney stone (Nephrolithiasis) => take w/ plenty of wate
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4
Q

Kaletra

Storage

  • Suspensions
  • Cap
A

Lopinavir-Ritonavir

  • Susp Sol’n => take w/ FOOD; REFRIGERATION b/c it contains EtOH
  • Film coated capsule: do not refrigerate
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5
Q

Viracept

A

Nelfinavir

  • Bad diarrhea
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6
Q

NORvir

  • Storage
  • SEs
A

RITonavir

Storage:

  • Cap: refrigerate
  • Tab/Sol: RT

SE
- Has bad GI, paresthesias

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7
Q

Invirase

A

SaQUINavir

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8
Q

Aptivus

  • SEs
  • BBW
A

TIPranavir

  • Has EtOH

SE

  • Fatal hepatotoxicity
  • Sulfa allergy

BBW: intracranial hemorrhage

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9
Q

Lexiva

A

FoSAMprenavir

  • Sulfa allergy
  • Suspension take on empty stomach
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10
Q

ReyaTAZ

  • SEs
A

ATAZanavir

  • Doesn’t increase lipid
  • Take QD

SEs

  • Cardiac abnormalities
  • Most DDI
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11
Q

Prezista

  • SEs
  • Direction to take
A

DaRUNavir

  • Sulfa allergy
  • Take BID with FOODs and ritonavir
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12
Q

Nucleoside Reverse Transcriptase Inhibitors (NRTI’s)

  • SE
A
  • Inhibits reverse transcriptase from convert RNA to DNA (Proviral DNA)
  • Lactic acidosis
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13
Q

Zerit

A

STAvudine

- SEs: 
   GI intolerance
   Pancreatitis 
   Peripheral neuropathy
   Lactic acidosis 
   Lipodystrophy
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14
Q

EPivir

A

LAMivudine

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15
Q

Retrovir

A

ZiDOvudine

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16
Q

Videx

  • Direction to take
  • SEs
A

DiDANosine

  • Take on empty stomach
  • SEs: Pancreatitis, peripheral neuropathy, retinal pigmentation, and lactic acidosis
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17
Q

Ziagen

A

Abacavir

  • SEs: Hypersensitivity rx HLA B*5701. D/c and do not re-challenge
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18
Q

Viread

  • SEs
A

Tenofovir

  • SEs: lactic acidosis, hepatotoxicity.
    Acute renal failure/Fanconi syndrome
    Osteoporosis
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19
Q

EMTRIva

A

EMTRIcitabine

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20
Q

Integrase inhibitors

- MOA

A
  • Inhibit HIV DNA integrate into host cell DNA
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21
Q

Insentress

  • MOA
A

Raltegravir

  • MOA: Inhibit HIV DNA integrate into host cell DNA
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22
Q

Tivicay

  • MOA
  • Age
  • SEs
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A

Dolutegravir

  • MOA: Inhibit HIV DNA integrate into host cell DNA
  • Age: for pt > 12 y.o
  • SEs: HA, insomnia
23
Q

Entry Inhibitors

- MOA

Study These Flashcards
A
  • Inhibit HIV binding and fusion therefore HIV can’t get inside celly
24
Q

Fuzeon

  • MOA
  • SEs
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A

Enfuvirtide

  • MOA: Target the gp120 or gp41 proteins on HIV’s surface
  • SE: may cause infection
25
Selzentry - MOA - Rec dose * Take with inhibitors * No inhibitors/inducers * Take with inducers - SEs
MAraviroc - Is CCR5 (Chemokine receptor type 5) blocker & antagonist - CCR5: is a protein which HIV uses to enter its target cells * * Rec initial dose is 150mg BID if also on inhibitors * * Rec dose is 300mg BID * * Rec initial dose 600mg BID if also on inducers - SE: hepatotoxicity, heart problem, orthostatic hypoTN
26
Non- Nucleoside Reverse Transcriptase Inhibitors (NNRTI's) | - MOA
- Inhibits reverse transcriptase from convert RNA to DNA (Proviral DNA)
27
Viramune
NeVIRApine - ne VYE ra peen
28
Intelence - SEs
ETRAvirine - et tra VIR reen - SEs: severe skin RASH
29
Rescriptor - SEs
Delavirdine - SE Rash, hepatotoxicity (least)
30
SUstiva - SEs - Preg Cat - Direction to take:
EFAvirenz - SEs: CNS sx: vivid dream, hallucination, false cannabinoid test - Preg Cat D - Take on empty stomach
31
Eduran - SEs
Rilpivirine - Ril pi VIR reen - SEs: depression, insomnia
32
Glycoproteins gp41 | - Function
- Helps to initiate the process of membrane fusion b/w virus and cell
33
Combivir => Come LZ
Zidovudine + Lamivudine
34
EPizicom => EP co Lam
Abacavir + Lamivudine
35
TriZivir LAZ = Trinity last
Zidovudine + Lamivudine + Abavavir
36
Truvada - Combo - Indication => TE
- Tenofovir + Emtricitabine Indication - FDA approved for PREVENTION of HIV infection in adults 1 tab PO QD
37
Atripla - Gold standard - Never give to - Take w/ ?
Efavirenz + Emtricitabine + Tenofovir - Never give to preg woman - Take QD on Empty stomach
38
CompleRa - Take with
- Emtricitabine + Tenofovir + Rilpivirine | - Take with FOOD 1 tab QD
39
Stribild: (TEEC) - Take w/ - CrCl
- Elvitegravir + cobicistat + emtricitabine + tenofovir disoproxil fumarate - Take with FOOD 1 tab QD - CrCl
40
Fxn of Cobicistat
- Enhancer to prolong the effect of Elvitegravir + emtricitabine + tenofovir
41
Vitravene - How to give - Indication
Fomivirsen - A shot directly into the disease eye x 2 separate by 2W - Approved for CMV who have failed other therapy
42
Rebetol, Copegus - Indication - SEs - Preg Cat
Ribavirin - Indication: Hepatitis C use in combo with interferon - SEs/CI: Sig heart disease - Preg Cat X
43
Pegylated Interferon - Brand - SEs
Pegasys; PEG-Intron - Depression & suicidal behavior
44
Egrifta - MOA - Indication - Dosage - CI
Tesamorelin Injection - MOA: growth hormone releasing factor analog Indication - Reduces excess abdominal fat in HIV-infected patients with lipodystrophy Dosage: - 2mg SC QD CI - Pregnant - Active malignancies
45
Fulyzaq - Indication
Crofelemer - Indication: Anti-diarrha for symptomatic relief of non-infectious diarrhea in pts with AIDs/HIV on anti-retrovial therapy
46
Dapsone - Indication
Sulfadiazine - CMV ppx
47
Daraprim - Indication - MOA
Pyrimethamine - Indication: antimalaria - Use in combination with leucovorin + sulfadiazine for toxoplasmosis treatment - MOA: inhibits parasitic dihydrofolate reductase
48
Foscarvir
Foscarnet - CMV - SEs: Nephrotoxic, seizure
49
Cytovene - Direction to take it
Ganciclovir - Take with FOOD
50
Vistide
Cidofovir - CMV - SE: severe nephrotoxicity = must taken with probenecid to help prevent kidney damage
51
Valcyte
Ganciclovir - CMV
52
Vitrasert
Ganciclovir implants
53
Vitravence
Fomiversen - Shot directly into the eye x 2 separate by 2wks
54
Triumeq
Abacavir + Lamiviudine + Dolutegravir
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