Hodge Podge

Question 1

tram track

Answer 1

membranoproliferative glomerulonephritis

Question 2

basketweave

Answer 2

Alport syndrome

Question 3

wire loops

Answer 3

lupus nephritis

Question 4

onion skin

Answer 4

hypertensive nephropathy or scleroderma

TTP, HUS

Question 5

foot process effacement

Answer 5

MCD

Question 6

spike and dome

Answer 6

membranous nephropathy

Question 7

subepithelial humps

Answer 7

post infectious glomerulonephritis

Question 8

soluble urokinase- type plasminogen activator receptor (suPAR)

Answer 8

FSGS

circulating permeability factor

Question 9

apoL1

Answer 9

part of a complex that lyses parasites
mutations lead to resistance to Trypanosome brucei rhodesiense (African sleeping sickness): does not bind trypanosomes protein that blocks apoL1
arterionephrosclerosis, FSGS, HIV nephropathy

Question 10

M-type PLA2

Answer 10

primary (idiopathic) membranous nephropathy

podocyte receptor

Question 11

NEP

Answer 11

congenital membranous nephropathy

Question 12

anti-streptolysin O

Answer 12

PSGN
throat infection
Ab against exotoxin B of S. progenies planted in GBM

Question 13

anti-DNAse B

Answer 13

PSGN

skin infection

Question 14

anti-hyaluronidase

Answer 14

PSGN

skin infection

Question 15

C3 nephritic factor

Answer 15

MPGN type 2

stabilizes C3 convertase

Question 16

factor H deficiency

Answer 16

MPGN

continued C3 activation

Question 17

galactose deficient IgA1

Answer 17

IgA nephropathy

Question 18

alpha 3 subunit of type IV collagen defect (COL4A3)

Answer 18

auto Ab: Goodpasture’s
or
AR Alport’s

Question 19

alpha 5 collagen type IV (COL4A5)

Answer 19

X linked Alport’s

Question 20

alpha 4 collagen type IV (COL4A4)

Answer 20

AR Alport’s

Question 21

Hep. C

Answer 21

polyartertitis nodosa
type 1 membranoproliferative glomerulonephritis
cryoglobinemia

Question 22

crescent

Answer 22

pauci-immune: vasculitis
lupus nephritis
Goodpasture
bad news bears

Question 23

schistocytes

Answer 23

seen in hemolytic anemia

HUS, TTP

Question 24

shigatoxin

Answer 24

HUS

Question 25

S. pneumoniae

Answer 25

HUS

Question 26

ADAMTS13

Answer 26

TTP | can't cut von Willebrand factor

Question 27

lupus

Answer 27

black females malar rash, arthralgia LOW C3, C4 anti-dsDNA

Question 28

full house IF

Answer 28

lupus nephritis

Question 29

polycystin-1/2

Answer 29

AD polycystic kidney disease

Question 30

fibrocystin

Answer 30

AR polycystic kidney disease

Question 31

ADPKD1/2

Answer 31

polycystic kidney disease

Question 32

citrate

Answer 32

inhibitor for Ca stones

Question 33

envelope crystal

Answer 33

Ca oxalate stones

Question 34

diamond crystal

Answer 34

uric acid stones

Question 35

coffin lid crystal

Answer 35

triple phosphate | magnesium ammonium phosphate

Question 36

hexagon crystal

Answer 36

cystine stones

Question 37

VHL

Answer 37

hereditary clear cell carcinoma inactivated mutation or hypermethylation normal: inhibits HIF that stimulates VEGF

Question 38

translocation or deletions on chromosome 3

Answer 38

sporadic clear cell carcinoma

Question 39

trisomy 7

Answer 39

papillary carcinoma

Question 40

MET

Answer 40

papillary carcioma mutated: activated TK that hepatocyte growth factor binds

Question 41

sicca syndrome

Answer 41

dry mouth and eyes due to inflammation of glands | LIGHT CHAIN disease

Question 42

meltzer's triad

Answer 42

cryoglobulinemia | purpura, arthralgia, weakness

Question 43

kimmelstiel wilson nodules

Answer 43

ovoid or sphereical, hyaline, sometimes laminated deposits of mucopolysacchrides, lipids, and fibrillary proteins within mesangium in periphery of glomerular tuft eventually squeeze capillaries shut DIABETIC NEPHROPATHY

Question 44

UTI cause

Answer 44

E. coli | Staph saprophyticus: sex. active women

Question 45

UTI pos. leukocyte esterase

Answer 45

produced by monocytes, neutrophils, and eosinophils | bacterial

Question 46

UTI pos. nitrite

Answer 46

gram negative

Question 47

UTI pos. urease

Answer 47

Proteus or Klebsiella

Question 48

UTI neg. urease

Answer 48

E. coli, Enterococcus