Hormones Flashcards Preview

Bryochemistry Last Exam > Hormones > Flashcards

Flashcards in Hormones Deck (20):
1

Examples of Peptide hormones?

INS, GLU, ACTH

2

Examples of steroid hormones?

Cortisol, beta-estradiol, testosterone

3

Basics of how Insulin binding works?

TK receptor phos. itself, Binds SH2, increases in PI3 and PKB

4

Basics of Epinephrine binding/signalling?

Adrenergic receptor. PIP pathway in Liver. cAMP in the muscle.

5

What are steroid hormones made from?

Cholesterol

6

How do steroid hormones get around? Examples?

Carrier proteins. Albumin, Transcortin. Sex Hor. Binding Protein.

7

Enzymes that cause rapid increase in cholesterol.

Cholesterol Esterases...Something about hydroxylation being a big fucking deal here...

8

Primary regulator of Steroid synthesis?

(Cholesterol Desmolase) 20, 22-lyase CYP11A

9

How is CYP11A activated?

Phosphorylation

10

Progesterone --> Cortisol. Name that enzyme.

CYP21A2

11

Progesterone --> Aldosterone. Name that enzyme.

CYP 11B2 (Aldosterone Synthase)

12

CYP 21A2 deficiency =

Adrenal hyperplasia --> Vomiting and infertility.

13

Aldosterone synthase deficiency -->

Hydroxylation problems. Electrolyte imbalance, vomiting, dehydration.

14

Describe thyroid hormone release.

Hypo --(TRH))--> Ant Pit --(TSH)--> Thyroid --> T3/4 -----> Inhibition of Hypo and Pit

15

Steroid Receptors are typically activated by....

dimerization

16

Steroid binding domain?

2 zinc fingers

17

What does cortisol do?

Degrades muscle, increases lipolysis, and immunosuppresses

18

What is Cushing Syndrome?

High cortisol due to over administration of glucocorticoids or ACTH secreting tumor.

19

Which enzyme adds in Iodine to the thyroid hormone?

Thyroid Peroxidase

20

Thyroglobulin forms ______ which form _______

MIT and DI. T3 and T4.