Flashcards in Hormones Deck (20):
Examples of Peptide hormones?
INS, GLU, ACTH
Examples of steroid hormones?
Cortisol, beta-estradiol, testosterone
Basics of how Insulin binding works?
TK receptor phos. itself, Binds SH2, increases in PI3 and PKB
Basics of Epinephrine binding/signalling?
Adrenergic receptor. PIP pathway in Liver. cAMP in the muscle.
What are steroid hormones made from?
How do steroid hormones get around? Examples?
Carrier proteins. Albumin, Transcortin. Sex Hor. Binding Protein.
Enzymes that cause rapid increase in cholesterol.
Cholesterol Esterases...Something about hydroxylation being a big fucking deal here...
Primary regulator of Steroid synthesis?
(Cholesterol Desmolase) 20, 22-lyase CYP11A
How is CYP11A activated?
Progesterone --> Cortisol. Name that enzyme.
Progesterone --> Aldosterone. Name that enzyme.
CYP 11B2 (Aldosterone Synthase)
CYP 21A2 deficiency =
Adrenal hyperplasia --> Vomiting and infertility.
Aldosterone synthase deficiency -->
Hydroxylation problems. Electrolyte imbalance, vomiting, dehydration.
Describe thyroid hormone release.
Hypo --(TRH))--> Ant Pit --(TSH)--> Thyroid --> T3/4 -----> Inhibition of Hypo and Pit
Steroid Receptors are typically activated by....
Steroid binding domain?
2 zinc fingers
What does cortisol do?
Degrades muscle, increases lipolysis, and immunosuppresses
What is Cushing Syndrome?
High cortisol due to over administration of glucocorticoids or ACTH secreting tumor.
Which enzyme adds in Iodine to the thyroid hormone?