Hormones - Effect & Mechanism 1 Flashcards Preview

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Flashcards in Hormones - Effect & Mechanism 1 Deck (10):
1

Aldosterone

  • Effects?
  • Mechanism of action?

Effects-

  • Increase Na+ reabsorption
  • increase H2O retention
  • increase renal K+ and H+ secretion

Mechanism of action-

  • Steroid hormone- direct modulation of gene expression

2

Cortisol

  • Effects?
  • Mechanism of action?

Effects-

  • Overall catabolic effect
  • Mediates stress response
  • Suppresses inflammation and immune response

Mechanism of action-

  • Steroid hormone- direct modulation of gene expression

3

Androgens

  • Effects?
  • Mechanism of action?

Effects-

  • Source of estrogen in postmenopausal women
  • Female hair distribution
  • Puberty in males (somewhat)

Mechanism of action

  • Steroid hormone- direct modulation of gene expression

4

Epinephrine/Norepinephrine

  • Effects?
  • Mechanism of action?

Effects-

  • Overall catabolic effect to mobilize energy stores

Mechanism of action-

  • Causes sodium efflux → increases Ca2+ → release of epi/norepi vesicles

5

Insulin

  • Effects?
  • Mechanism of action?

Effects-

  • Decrease blood glucose levels by increasing anabolic functions

Mechanism of action-

  • Tyrosine kinase (dephosphorylates)

6

Glucagon

  • Effects?
  • Mechanism of action?

Effects-

  • Increases blood glucose levels by increasing catabolic functions

Mechanism of action-

  • Increases cAMP → activates PKA (phosphorylates) (Gs)

7

Somatostatin

  • Effects?
  • Mechanism of action?

Effects-

  • Decreases insulin and glucagon
  • Decreases GIT motility
  • Decreases GIT secretions

Mechanism of action-

  • Decrease cAMP (Gi)

8

Growth Hormone

  • Effects?
  • Mechanism of action?

Effects-

  • Increase bone growth, organ growth, protein synthesis and cell growth
  • Lipolysis
  • Increase blood sugar levels

Mechanism of action-

  • Increase tyrosine kinase action to modulate gene expression

9

Prolactin

  • Effects?
  • Mechanism of action?

Effects-

  • Breast development and milk production
  • Inhibits ovulation

Mechanism of action-

  • Increase tyrosine kinase action to modulate gene expression

10

ADH

  • Effects?
  • Mechanism of action?

Effects-

  • Increase water reabsorption and vasoconstriction

Mechanism of action-

  • Increase cAMP at kidney and increase IP3/DAG and Ca2+ at blood vessels (Gs and Gq)