Hormones - Effect & Mechanism 2 Flashcards Preview

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Flashcards in Hormones - Effect & Mechanism 2 Deck (11):
1

Oxytocin

  • Effects?
  • Mechanism of action?

Effects-

  • Milk let down response or uterine contractions during labor

Mechanism of action-

  • Increase IP3/DAG and Ca2+ (Gq)

2

Thyroid Hormone

  • Effects?
  • Mechanism of action?

Effects-

  • Increase BMR

Mechanism of action-

  • Enters the nucleus directly (T3)

3

Parathyroid Hormone

  • Effects?
  • Mechanism of action?

Effects-

  • Increases calcium reabsorption from bone
  • Increases phosphate secretion

Mechanism of action-

  • Via IP3 and cAMP (Gq and Gs)

4

Vitamin D3 (Calcitrol)

  • Effects?
  • Mechanism of action?

Effects-

  • Increase Ca2+ and PO4 reabsorption form GIT, promote bone mineralizaton (low concentrations)

Mechanism of action-

  • Steroid hormone – direct modulation of gene expression

5

Calcitonin

  • Effects?
  • Mechanism of action?

Effects-

  • Helps in fetus and neonate bone formation

Mechanism of action-

 

6

Testosterone

  • Effects?
  • Mechanism of action?

Effects-

  • Spermatogenesis and male secondary sex characteristic development

Mechanism of action-

  • Steroid hormone- binds to intracellular receptors to modulate gene expression

7

Estrogen

  • Effects?
  • Mechanism of action?

Effects-

  • Secondary female sex characteristics
  • Follicular phase of menstrual cycle
  • Bone growth and development

Mechanism of action-

  • Steroid hormone – binds to intracellular receptors to modulate gene expression

8

Progesterone

  • Effects?
  • Mechanism of action?

Effects-

  • Luteal phase of menstrual cycle
  • Inhibits uterine excitability during pregnancy

Mechanism of action-

  • Steroid hormone – binds to intracellular receptors to modulate gene expression

9

Luteinizing Hormone

  • Effects?
  • Mechanism of action?

Effects-

  • Stimulates ovulation
  • Formation of corpus luteum
  • Synthesis and secretion of estrogen in ovaries and testosterone in testes

Mechanism of action-

  • Increase cAMP (Gs)

10

Follicle Stimulation Hormone

  • Effects?
  • Mechanism of action?

Effects-

  • Stimulates growth of ovarian follicles and estrogen secretion
  • Promotes sperm maturation in testes

Mechanism of action-

  • Increase cAMP (Gs)

11

Human Chorionic Gonadotropin (hCG)

  • Effects?
  • Mechanism of action?

Effects-

  • Increase estrogen and progesterone synthesis in corpus luteum of pregnancy,
  • Supports sexual differentiation of male fetus

Mechanism of action-

  • Increase cAMP (Gs)