HSCT

Question 1

For which kinds of diseases we can perform HSCT?

Answer 1

Onco-hematological diseases, autoimmune diseases, genetic diseases (immunodeficiencies), anemia.
Autologous or allogenic setting for malignant diseases and non-malignant diseases.

Question 2

Types of donors and haploidentical HSTC

Answer 2

MSD, MUD, MMUD and haploidentical donor.

Question 3

HSCT sources

Answer 3

Bone marrow
Peripheral blood
Cord blood

Question 4

Graft versus host disease

Answer 4

T and B lymphocytes that are transplanted from the donor can recognize as foreign the antigens of the recipient attacking the host cells and tissues.
Necrosis and organ failure.
Acute and chronic.
Gastrointestinal tract.

Question 5

To improve the HSCT we can…

Answer 5

Find the most suitable donor
Use the best immune prophylaxis and myeloablative regimen
Eliminate potential alloreactive T and B cells from the graft to avoid GVHD

Question 6

Why can we use the donor lymphocytes infusion?

Answer 6

Patients with hematological tumors to induce the graft versus leukemia reaction to eliminate potential residual leukemic blasts.