HYPERLIPOPROTEINEMIA

Question 1

can be a single gene disorder or multifactorial with complex inheritance patterns

Answer 1

primary

Question 2

example of primary?

Answer 2

familial hypercholesteremia, an autosomal dominant receptor disease chromosome 19

Question 3

elevated cholesterol in heterozygotes?

Answer 3

50% fewer receptors, 2-3x increase in total cholesterol

Question 4

elevated cholesterol in homozygotes?

Answer 4

virtually no normal receptors, 5-6x increase in total cholesterol

Question 5

clinical features of familial hypercholesteremia?

Answer 5

premature atherosclerosis
increased risk of MI
tendinous xanthomas

Question 6

examples of secondary?

Answer 6

DM type I/II
hypothyroidism
renal failure
alcohol ingestion
liver disease

Question 7

treatment?

Answer 7

statins (lovastatin)