Hypersensitivity Flashcards Preview

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Flashcards in Hypersensitivity Deck (25)
1

what type is this?
IgE
soluble antigen
mast cell activation

type 1- allergy and asthma

2

what type is this?
IgG
cell surface receptor or matrix
activates complement

type 2 drugs and chronic urticaria

3

what type is this?
IgG
soluble antigen
activates complement

type 3 - arthus reaction

4

Th1 and 2 cells or cytotoxic t cell
soluble antigens or cell antigens
macrophage and eosinophil activation
cytotoxicity
dermatitis, chronic asthma, allergic rhinitis

Type 4

5

what does IgE trigger

mast cell degranulation

6

what is IgE produced by

plasma B cells in lymph nodes or locally

7

what does a CD4 t helper 1 cell cause

macrophage activation

8

what does CD4 TH2 cause

B cell acitvation

9

what does a CD8 cytotoxic t cell cause

cell lysis

10

name some allergens

pollen
animals
mold spores
dust mite faeces
insect venom
vaccines
drugs
medicine
food
plants
synthetic chemicals
metals

11

what is degranulation

is a cellular process that releases antimicrobial cytotoxic molecules from secretory vesicles called granules found inside some cells.

12

what can result from an allergen entering the blood stream

hives (urticaria)
anaphylaxis and cv collapse

13

name some inflammatory mediators

lipids
toxic mediators
cytokines
enzymes

14

what cell favours IgE response

Th2 T cells

15

what cell is stimulated in allergy and asthma

mast cell usually found at mucosal surfaces

soluble antigen

16

what type would you find non soluble antigens

type 2

cytoxic

17

what cells are stimulated in type 3

phagocytes

immune complex disease

18

what cells are stimulated in type 4

macrophages and eosinophils

delayed type hypersensitivity

19

what do prostaglandins do

increase vascular permeability
increase platelet aggregation
activates neutrophils

20

what do chemokines do

attract macrophages and neutrophils

21

what other cells are also involved In allergy

basophils and eosinophils

can cause tissue damage

22

what type involves IgG

2 and 3

23

what antibodies are involved in type 3 (immune complex)

IgG and IgM

24

where might immune complexes be deposited in type

kidneys
blood vessels
synovial membranes
skin
systemic

25

what are the features of type 4

complement is not involved
entirely cell mediated
delayed hypersensitivity (DTH)
involves macrophages
granulomas eg tubercles seen in tuberculosis