Hyperthyroidism, Hypothyroidism/Thyroiditis 2 Flashcards Preview

Endocrine week 3 > Hyperthyroidism, Hypothyroidism/Thyroiditis 2 > Flashcards

Flashcards in Hyperthyroidism, Hypothyroidism/Thyroiditis 2 Deck (18):
1

What are the symptoms of hyperthyroidism?

  • Weight loss despite increased apetite 
  • Palpitations/ rapid pulse 
  • Sweating and heat intolerance 
  • Tiredness and weak muscles 
  • Nervousness, irritability and shakiness 
  • Mood swings or aggressive behaviour 
  • Frequent loos bowel movements 
  • Warm, moist hands 
  • Thirst 
  • Passing larger than usual amounts of urine 
  • Itchiness 
  • An enlarged thyroid gland (can be in hypo as well tho)

2

What are some of the classic eye features seen in hyperthyroidism ?

  • Lid retraction 
  • Lid lag chemosis 
  • Proptosis 
  • Visual loss 
  • Diplopia

3

What is the thyroid antibody which is associated with hyperthyroidism mainly ?

TSH receptor antibody 

4

What are the causes of hyperthyroidism ?

Autoimmune graves disease 

Nodular thyroid - Multi-nodular goitre, toxic nodule 

Thyroiditis (inflammation):

  • Iodine - supplement, amiodarone, thyroxine 
  • Medications - lithium, amiodarone, thyroxine 

 

5

What drug can cause both hypothyroidism and hyperthyroidism ?

Amiodarone 

6

What is a thyroid storm ?

Severe hyperthyroidism. Emergency 

7

What are the symptoms of a thyroid storm ?

8

What is the management of thyroid storm ?

  • Lugols iodine 
  • Glucocorticoids (calm down immune system)
  • B-blockers 
  • Fluid monitoring 

9

What is the treatment of hyperthyroidism ?

  • Carbimazole 
  • Propylthiouracil (if pregnant)
  • B-blocker for rapid control of symptoms 

10

50% of patients will relapse after oral treatment for hyperthyroidism - what can be done for those who relapse ?

  • Radioiodine 
  • Thyroidectomy 

11

What does radioiodine therapy carry a big risk of ?

Causing the patient to develop hypothyroidism

12

What is thyroiditis ?

It is inflammation of the thyroid gland which can either cause high or low levels of thyroid hormone 

13

What are the different types of thyroiditis ?

  • Graves 
  • Hashimotos 
  • DeQuervians (sub-acute (viral))
  • Post-partum (after pregnancy)
  • Drug-induced - amiodarone, lithium 
  • Acute thyroiditis/supprative (bacterial)

14

Describe what sub-acute/ De-Quervians is ?

  • May be triggered by viral infection 
  • May have associated sore throat and viral symptoms e.g. fever 
  • Usually self-limiting 

15

What are the thyroid hormone results of sub-acute thyroiditis/ De-Quervians? 

  1. T4 high and TSH low in early stage 
  2. T4 low and TSH high in late stage 
  3. The results then normalise 

Refer to case 7 slide 53 for example 

A image thumb
16

How common is amiodarone induced thyroid dysfunction?

  • 2% will develop thyrotoxicosis 
  • 13% will develop hypothyroidism 

17

What are the thyroid hormone results for primary, sub-clinical and secondary hyperthyroidism ?

  • Primary - TSH low, T4/T3 high 
  • Sub-clinical - TSH low, T4/T3 normal 
  • Secondary - TSH high, T4/T3 high 

18

Have a look at the cases at the end of this lecture 

They are good