Hypothalamic and ANterior Pituitary Disorders Flashcards Preview

Endocrinology > Hypothalamic and ANterior Pituitary Disorders > Flashcards

Flashcards in Hypothalamic and ANterior Pituitary Disorders Deck (26):
1

GnRH stimulates what

FSH and LH
(GnRH is a releasing hormone, made in the hypothalamus, we need to know what all of these do.

2

GHRH stimulates release of

GH

3

TRH stimulates release of

TSH and Prolactin

4

VIP stimulates what

Prolactin

5

CRH and ADH stimulates release of what?

ACTH

6

GH deficiency leads to what in children

Short stature

7

GH deficiency in adults leads to

Various problems such as lipid metabolism issues

8

FSH deficiency =

Infertility

9

LH deficiency =

Men: hypogonadism and reduced sperm count
Women: hypogonadism, amenorrhea, oligomenorrhea

10

TSH deficiency=

thyroid deficiency

11

ACTH deficiency=

hypoadrenalism; loss of pigmentation

12

ADH deficiency

Diabetes Insipidus

13

Oxytocin deficiency

failure of milk letdown, post-partum bleeding

14

Only HUMAN growth hormone is effective

truth

15

Handout: Define Long Loop negative feedback

Target gland hormone regulates secretion at hypothalamic and pituitary level

16

Handout: Define short loop feedback

Pituitary gland hormone feeds back and regulates hypothalamic hormone release.

17

Hanout: Define ultrashort loop feedback:

Hypothalamic hormone influences the secretion of its own hormone secreting neuron

18

Hypopituitarism definition

Partial or complete loss of secretion of one or more pituitary hormones with clinical manifestations of pituitary failure.
Loss of isolated releasing hormones is called monotropic hypopituitarism
Loss of various releasing hormones is polytropic

19

Pathoma: Non-functional tumors of the anterior pituitary gland often present with what?

Something called mass effect where you get bitemporal hemianopsia due to compression of the optic chiasm, headache, and hypopituitarism due to compression of normal pituitary tissue.

Functional tumors present with features based on the type of hormone produced

20

What is the most common pituitary adenoma?

Prolactinoma

21

How does prolactinoma present

galactorrhea (continuous flow of breast milk, amenorrhea (no menstrual cycle)

22

Growth hormone cell adenoma in children?

Gigantism, increased linear bone growth because the epiphyses are not fused.

23

Growth hormone cell adenoma in adults

acromegaly- enlarged bones of hand, feet, and jaw. Growth of visceral organs leads to cardiac failure

24

Why is Diabetes mellitus often present in ppl with a growth hormone adenoma?

Because GH decreases glucose uptake by cells

25

ACTH cell adenoma

TOO much ACTH leading to Cushings SYndrome

26

Not done

ok