Flashcards in Hypothalamic and ANterior Pituitary Disorders Deck (26):
1
GnRH stimulates what
FSH and LH
(GnRH is a releasing hormone, made in the hypothalamus, we need to know what all of these do.
2
GHRH stimulates release of
GH
3
TRH stimulates release of
TSH and Prolactin
4
VIP stimulates what
Prolactin
5
CRH and ADH stimulates release of what?
ACTH
6
GH deficiency leads to what in children
Short stature
7
GH deficiency in adults leads to
Various problems such as lipid metabolism issues
8
FSH deficiency =
Infertility
9
LH deficiency =
Men: hypogonadism and reduced sperm count
Women: hypogonadism, amenorrhea, oligomenorrhea
10
TSH deficiency=
thyroid deficiency
11
ACTH deficiency=
hypoadrenalism; loss of pigmentation
12
ADH deficiency
Diabetes Insipidus
13
Oxytocin deficiency
failure of milk letdown, post-partum bleeding
14
Only HUMAN growth hormone is effective
truth
15
Handout: Define Long Loop negative feedback
Target gland hormone regulates secretion at hypothalamic and pituitary level
16
Handout: Define short loop feedback
Pituitary gland hormone feeds back and regulates hypothalamic hormone release.
17
Hanout: Define ultrashort loop feedback:
Hypothalamic hormone influences the secretion of its own hormone secreting neuron
18
Hypopituitarism definition
Partial or complete loss of secretion of one or more pituitary hormones with clinical manifestations of pituitary failure.
Loss of isolated releasing hormones is called monotropic hypopituitarism
Loss of various releasing hormones is polytropic
19
Pathoma: Non-functional tumors of the anterior pituitary gland often present with what?
Something called mass effect where you get bitemporal hemianopsia due to compression of the optic chiasm, headache, and hypopituitarism due to compression of normal pituitary tissue.
Functional tumors present with features based on the type of hormone produced
20
What is the most common pituitary adenoma?
Prolactinoma
21
How does prolactinoma present
galactorrhea (continuous flow of breast milk, amenorrhea (no menstrual cycle)
22
Growth hormone cell adenoma in children?
Gigantism, increased linear bone growth because the epiphyses are not fused.
23
Growth hormone cell adenoma in adults
acromegaly- enlarged bones of hand, feet, and jaw. Growth of visceral organs leads to cardiac failure
24
Why is Diabetes mellitus often present in ppl with a growth hormone adenoma?
Because GH decreases glucose uptake by cells
25
ACTH cell adenoma
TOO much ACTH leading to Cushings SYndrome
26