Hypothalamic Control of the Pituitary Gland Flashcards Preview

Digestive, Endocrine, and Metabolic Systems > Hypothalamic Control of the Pituitary Gland > Flashcards

Flashcards in Hypothalamic Control of the Pituitary Gland Deck (10):
1

What six hormones act on the anterior pituitary?

Thyroid-releasing hormone (TRH)
Corticotropin-releasing hormone (CRH)
Gonadotropin-releasing hormone (GnRH)
Growth hormone-releasing hormone (GHRH)
Somatostatin
Prolactin-inhibiting hormone (PIH)

2

List the effects of each of the hypothalamic hormones when they come into contact with the pituitary.

Thyroid-releasing hormone (TRH)
Stimulates release of TSH

Corticotropin-releasing hormone (CRH)
Stimulates release of ACTH

Gonadotropin-releasing hormone (GnRH)
Stimulates release of LH and FSH

Growth hormone-releasing hormone (GHRH)
Stimulates release of GH

Somatostatin
Inhibits release of GH

Prolactin-inhibiting hormone (PIH)
Stimulates decreased release of prolactin

3

Describe how prolactin hormone works.

It binds to a cytokine receptor in the anterior pituitary that activates Janus kinase, a kinase that phosphorylates tyrosine residues.

4

Prolactin ultimately activates JAK-STATs. What are those?

Janus kinases – signal transducers and activators of transcription

5

Why are prolactin receptors called cytokine receptors?

Because cytokine receptors also work via JAK-STATs

6

Prolactin causes what in the mammary glands?

Mammogenesis
Lactogenesis
Galactopoiesis

7

What symptoms are indicative of hyperprolactinemia?

Galactorrhea
Amenorrhea
Loss of libido (because excess prolactin causes decreased release of GnRH by the hypothalamus)

8

What is Sheehan's syndrome?

Hemorrhagic destruction of the pituitary resulting in hypoprolactinemia

9

What kind of G protein do CRH and GHRH bind to?

Gs

10

ACTH is a derivative of ___________.

POMC

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