Hypothalamic Releasing and Inhibiting Hormones and related materials Flashcards Preview

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Flashcards in Hypothalamic Releasing and Inhibiting Hormones and related materials Deck (17):
1

hypothalamus---Anterior Pituitary--Target tissue/Response

thyrotropin releasing hormone

TRH stimulates thyroid stimulating hormone release from AP

TSH stimulates T3 and T4 hormones from thyroid

2

hypothalamus--Anterior Pituitary--Target tissue/Response

GnRH

Gonadotropin Releasing hormone stimulates LH and FSH release from AP
FSH acts to develop the ovaries, spermatogenesis in the testes

LH stimulates ovulation, estrogen, progesterone production in ovaries, and testosterone production in the testes

3

hypothalamus--Anterior Pituitary--Target tissue/Response

CRH

corticotropin releasing hormone stimulates adrenocorticotropic hormone from AP, which stimulates cortisol release

stimulates adrenal cortex to release cortisol

4

hypothalamus--Anterior Pituitary--Target tissue/Response

GHRH

stimulates release of growth hormone from AP which stimulates growth, decreases glucose uptake, increases protein synthesis, organ size, and lean body mass

5

hypothalamus--Anterior Pituitary--Target tissue/Response

stomatostatin

inhibits release of GH and TSH from AP

6

hypothalamus--Anterior Pituitary--Target tissue/Response

Prolactin inhibiting hormone

aka dopamine

inhibits prolactin release from AP

prolactine stimulates lactation and inhibits FSH, LH, and GnRH

7

bitemporal hemianopsia

pituitary adenoma compresses the optic chiasm, causing issues with peripheral vision

8

pituitary adenoma that compresses itself =

hypopituitarism , causes headaches

9

Follicule Stimulating hormone

stimulated by
inhibited by
effect

gonadotroph, secreted by basophils

Stimulated by

GnRH from hypothalamus

inhibited by

inhibin
feedback inhibition by estrogen in females

effect

FSH stimulates ovarian follicle maturation and estrogen production in females, stimulates sertoli cells to produce sperm in males

10

Luteinizing Hormone

stimulated by
inhibited by
effect

gonadotroph, secreted by basophils

stimulated by

GnRG from hypothalamus

inhibited by

feedback inhibition by estrogen and progesterone in females, and testosterone in males

effect

LH triggers ovulation and stimulates ovarian production of estrogen and progesteron in females

promotes Leydig cell production of testosterone in males

11

Adrenocroticotropic Hormone (ACTH)

stimulated by
inhibited by
effect

corticotroph, secreted by basophils

stimulated by

CRH from hypothalamus

inhibited by

feedback inhibition by glucocorticoids (cortisol)

effect: stimulates adrenal cotext to release glucocorticoids and androgens

12

Thyroid stimulating hormone (TSH)

stimulated by
inhibited by
effect

thyrotrophs (basophils)

stimulated by

TRH from hypothalamus

inhibited by

feedback inhibition by thyroid hormones (T3/T4)

Effect

stimulates thyroid gland to release T3/T4 to control metabolism

13

Prolactin

stimulated by
inhibited by
effect

mammotrophs/lactotrophs (acidophils)

stimulated by

prolactin releasing hormone and TRH, from from hypothal

inhibited by

prolactin inhibiting hormone

effect

stimulates milk production and promotes lactation
inhibits GnRH and thus FSH & LH

14

Growth Hormone (GH)

stimulated by
inhibited by
effect

somatotrp[hs (acidophils)

stimulated by

GHRH from hypothalamus
hypoglycemia, low levels of FAs, high blood levels of a.a and exercise

effect

indirectly stimulates overall growth of bone and soft tissue via production of insulin like growth factor-1 aka somatomedin

15

Kallman Syndrome

hypogonadotropic hypogonadism

genetic mutation that prevents migration of GnRH neurons to arcuate nucleus/olfactory neurons

16

ADH

where it is produced, stored, stimulant, receptors for ADH, and effects

produced mostly in the supraoptic nuclei, although some produced in the paraventricular nuclei

stored in herring bodies in the pars nervosa

hypothalamic baroreceptors and osmoreceptors monitor salt and pressure levels, stimulate pars nervosa to secrete ADH

acts on V2 receptors in distal convoluted collecting ducts, causes water retention and concentrates urine

POTENT vasoconstrictor at high doses (via V1 receptors)


17

Oxytocin

where it is produced, stored, stimulant, receptors for ADH, and effects

produced by paraventricular nucleus, stored in posterior pit.

helps uterine contractions during child bird, facilitates milk ejection

"feel good hormone" released during cuddling