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Pathophysiology > IBS > Flashcards

Flashcards in IBS Deck (10):
1

Is IBS common?

Yes

2

What kind of disorder is IBS

It is a sensory and motility disorder of the bowel

3

Et. of IBS

Unclear

Proposed links: lactose, stress, smoking, diet

4

Patho of IBS

Malabsorption of polyols and fermented CHO
Normal flora process this and as a by product make gas -> flatulence
This disrupts the fx of the GI tract
Molecular signalling defect in serotonin
IBS Mnfts and fx problems occur

5

What is the function of serotonin

It is involved with secretion, perfusion, motility and pain reflex)

6

What cells secrete serotonin

Enterochromaffin cells

7

Mnfts of IBS

Varied severity
Flatulence
Alt. diarrhea, constipation
Abdm pain and discomfort
Mucoid stools

8

Dx of IBS

Exclude organic disease

Various scopes (endoscopy, colonoscopy, sigmoidoscopy)

Presentation

9

Tx of IBS

Avoid offending foods
Decrease stress
PRN Meds: antidiarrheals, antispasmodics, laxatives and SOMETIMES abx

10

Why do we caution with use of Abx?

It wipes out normal flora so that Mnfts of IBS will decrease but if too much abx are used, then we have a total loss of normal flora and the risk of infection rises a lot