ID: RNA Viruses Flashcards Preview

Unit 6: Pathology > ID: RNA Viruses > Flashcards

Flashcards in ID: RNA Viruses Deck (24)
Loading flashcards...
1
Q

If someone is deficient in the MAC attack complex - complement 5, 6, 7,8 - what are they susceptible to?

A

Neisseria infections

2
Q

Why do RNA viruses have a high rate of mutations?

A

RNA polymerases dont proofread

3
Q

What are the most common viruses that cause the common cold?

A

rhinovirus - a picornavirus

coronavirus

4
Q

Besides the common cold, what else can the coronavirus cause?

A

SARS

5
Q

What specifically causes cold like symptoms?

A

bradykinin release

6
Q

What type of influenza is most common and most severe?

A

type A

7
Q

What mediates fusion of the influenza virus?

A

hemagluttinin

8
Q

If someone has an infection with the flu what are they susceptible to and why?

A

destruction of the ciliated epithelium –> bacterial infection

examples: S pneumonia, S aureus

9
Q

What illness does RSV cause?

A

bronchiolitis and pneumonia in kids <1

10
Q

What cells are pathologically present in a measles infection?

A

warthin finkeldey giant cells

11
Q

What infection “Four Ds and Four Cs” - 4 day fever, cough, coryza (head cold), conjunctivitis

A

Measles

12
Q

Describe the rash that is pathognomonic for Measles

A

KOPLIK spots:

  • grey spots on red base
  • T cell mediated vasculitis
  • begins on face and spreads to trunk
13
Q

What is an unfortunate complication of Measles?

A

Subacute sclerosing panencephalitis - slow neurodegen. disorder years after infection

14
Q

What comprises TORCH

A
T toxoplasmos
O other - coxsackie, syphilis, varicella, chlamydia, HIV
R  rubella
C CMV
H HSV2 

all are vertically transmitted diseases

15
Q

What infection “fever, painful swelling of the parotid gland with possible testicular swelling”

A

Mumps

16
Q

What are some complications of Mumps

A
  • pancreatitis

- Meningoencephalitis

17
Q

What is the most common cause of diarrhea worldwide?

A

rotavirus

18
Q

What is the vector for yellow fever?

A

Aedes mosquito

19
Q

What cells are pathognomonic for yellow fever?

A

councilman bodies in the liver

20
Q

What disease causes the MOST widespread destruction of tissues?

A

Ebola virus

21
Q

What disease does west nile cause?

A

mononuclear meningoencephaltiis

22
Q

Describe how HIV is able to enter CD4 cells

A

GP120 binds CD4

Coreceptor CXC4 or CCR5 must be present

23
Q

Name the aproximate CD4 counts:

  1. constitutional symptoms and start of opportunistic infections
  2. TB
  3. kaposi, lymphoproliferative disorders
A
  1. <150
24
Q

What are the most common causes of these infections in AIDs patients:

  1. respiratory infection
  2. Meningitis
  3. Encephalitis
  4. skin infection
  5. diarrhea
A
  1. PJP
  2. Cryptococcus
  3. HSV
  4. S Aureus
  5. Cryptosporidium