If someone is deficient in the MAC attack complex - complement 5, 6, 7,8 - what are they susceptible to?
Why do RNA viruses have a high rate of mutations?
RNA polymerases dont proofread
What are the most common viruses that cause the common cold?
rhinovirus - a picornavirus
Besides the common cold, what else can the coronavirus cause?
What specifically causes cold like symptoms?
What type of influenza is most common and most severe?
What mediates fusion of the influenza virus?
If someone has an infection with the flu what are they susceptible to and why?
destruction of the ciliated epithelium –> bacterial infection
examples: S pneumonia, S aureus
What illness does RSV cause?
bronchiolitis and pneumonia in kids <1
What cells are pathologically present in a measles infection?
warthin finkeldey giant cells
What infection “Four Ds and Four Cs” - 4 day fever, cough, coryza (head cold), conjunctivitis
Describe the rash that is pathognomonic for Measles
- grey spots on red base
- T cell mediated vasculitis
- begins on face and spreads to trunk
What is an unfortunate complication of Measles?
Subacute sclerosing panencephalitis - slow neurodegen. disorder years after infection
What comprises TORCH
T toxoplasmos O other - coxsackie, syphilis, varicella, chlamydia, HIV R rubella C CMV H HSV2
all are vertically transmitted diseases
What infection “fever, painful swelling of the parotid gland with possible testicular swelling”
What are some complications of Mumps
What is the most common cause of diarrhea worldwide?
What is the vector for yellow fever?
What cells are pathognomonic for yellow fever?
councilman bodies in the liver
What disease causes the MOST widespread destruction of tissues?
What disease does west nile cause?
Describe how HIV is able to enter CD4 cells
GP120 binds CD4
Coreceptor CXC4 or CCR5 must be present
Name the aproximate CD4 counts:
- constitutional symptoms and start of opportunistic infections
- kaposi, lymphoproliferative disorders
What are the most common causes of these infections in AIDs patients:
- respiratory infection
- skin infection
- S Aureus