ID: RNA Viruses Flashcards Preview

Unit 6: Pathology > ID: RNA Viruses > Flashcards

Flashcards in ID: RNA Viruses Deck (24):
1

If someone is deficient in the MAC attack complex - complement 5, 6, 7,8 - what are they susceptible to?

Neisseria infections

2

Why do RNA viruses have a high rate of mutations?

RNA polymerases dont proofread

3

What are the most common viruses that cause the common cold?

rhinovirus - a picornavirus
coronavirus

4

Besides the common cold, what else can the coronavirus cause?

SARS

5

What specifically causes cold like symptoms?

bradykinin release

6

What type of influenza is most common and most severe?

type A

7

What mediates fusion of the influenza virus?

hemagluttinin

8

If someone has an infection with the flu what are they susceptible to and why?

destruction of the ciliated epithelium --> bacterial infection

examples: S pneumonia, S aureus

9

What illness does RSV cause?

bronchiolitis and pneumonia in kids <1

10

What cells are pathologically present in a measles infection?

warthin finkeldey giant cells

11

What infection "Four Ds and Four Cs" - 4 day fever, cough, coryza (head cold), conjunctivitis

Measles

12

Describe the rash that is pathognomonic for Measles

KOPLIK spots:
-grey spots on red base
-T cell mediated vasculitis
-begins on face and spreads to trunk

13

What is an unfortunate complication of Measles?

Subacute sclerosing panencephalitis - slow neurodegen. disorder years after infection

14

What comprises TORCH

T toxoplasmos
O other - coxsackie, syphilis, varicella, chlamydia, HIV
R rubella
C CMV
H HSV2

all are vertically transmitted diseases

15

What infection "fever, painful swelling of the parotid gland with possible testicular swelling"

Mumps

16

What are some complications of Mumps

-pancreatitis
-Meningoencephalitis

17

What is the most common cause of diarrhea worldwide?

rotavirus

18

What is the vector for yellow fever?

Aedes mosquito

19

What cells are pathognomonic for yellow fever?

councilman bodies in the liver

20

What disease causes the MOST widespread destruction of tissues?

Ebola virus

21

What disease does west nile cause?

mononuclear meningoencephaltiis

22

Describe how HIV is able to enter CD4 cells

GP120 binds CD4
Coreceptor CXC4 or CCR5 must be present

23

Name the aproximate CD4 counts:
1. constitutional symptoms and start of opportunistic infections
2. TB
3. kaposi, lymphoproliferative disorders

1. <150

24

What are the most common causes of these infections in AIDs patients:
1. respiratory infection
2. Meningitis
3. Encephalitis
4. skin infection
5. diarrhea

1. PJP
2. Cryptococcus
3. HSV
4. S Aureus
5. Cryptosporidium