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Flashcards in Idiopathic Thrombocytopenia Purpura Deck (10)
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Define idiopathic thrombocytopenia purpura

idiopathic = unknown cause; thrombocyto = platelet; purpura = purple spotting --- one level of a three-level system gauging micro-bleeds of the skin

1

Idiopathic thrombocytopenia purpura (ITP) is a disorder of _______.

decreased platelet numbers

2

Which form of ITP, acute or chronic, is usually self-resolving?

Acute, typically seen in children. Chronic form persists in adults and must be continually treated.

3

What are the three levels of micro-bleeds?

petechia (spots ~1-2 mm), purpura (spots ~ 0.3-1cm), ecchymoses (>1cm)

4

What are the clinical features of ITP?

easy bleeding w/ increased bleed time, micro-bleeds in capillaries, and easy bruising and nosebleeds.

5

Why does ITP exhibit a greatly reduced platelet count?

Decr. production and/or incr. destruction of platelets; latter removed from blood by spleen

6

ITP exhibits a delayed prothrombin consumption; how might this reflect clinically?

prolonged bleed times; prothrombin is slow to become thrombin, which delays conversion of fibrinogen to fibrin, which ultimately forms the clot.

7

Why might someone with ITP exhibit bleeding from membranes such as the oral mucosa?

Mucosal linings (and the skin) are easily bruised in ITP

8

Which form of ITP (acute or chronic) is due to autoimmunity?

The chronic form: antibodies to platelets are present

9

How might you treat idiopathic thrombocytopenia purpura?

SPLENECTOMY, immunosuppression therapy, or corticosteroids