IHD PK Flashcards
1
Q
does nitroglycerin have high or low oral F?
A
very low
2
Q
does nitroglycerin have long or short half life?
A
short (2-3 min)
3
Q
how are nitrates transformed into NO? How does this compare to how sodium nitroprusside is made into NO?
A
- nitrates made into NO by enzymatic biotransformation
2. nitroprusside is spontaneously converted to NO by reducing substrates such as glutathione
4
Q
why does nitroglycerin have such low oral F?
A
extensively metabolized with high first-pass metabolism in teh GI tract
5
Q
how is nitroglycerin deactivated during first pass metabolism?
A
enzymatically de-nitrtaed to glycerol dinitrate, glycerol mononitrate and glycerol in the liver, RBC and
