III - Topnotch Pharma Flash Cards - Drugs for Smooth Muscles Preview

pharma > III - Topnotch Pharma Flash Cards - Drugs for Smooth Muscles > Flashcards

Flashcards in III - Topnotch Pharma Flash Cards - Drugs for Smooth Muscles Deck (28):
1

more likely to block autonomic receptors, also has alpha1 blocking and local anesthetic effect

1st Generation antihistamines (TOPNOTCH)

2

Reversible blockade of histamine H1-receptor sites on tissues, No sedation and antimuscarinic effects

2nd Generation antihistamines (TOPNOTCH)

3

may cause arrhythmia due to blockade of cardiac potassium channels

acrivastine, astemizole, cetirizine, loratadine, and terfenadine (TOPNOTCH)

4

reduction of nocturnal acid secretion in gastirc and duodenal ulcer

H2 antagonists (TOPNOTCH)

5

True or False: H2 antagonists have H1-blocking effect

FALSE (TOPNOTCH)

6

True or False: Ranitidine is a CYP450 inhibitor

TRUE, but weak inhibitor only (TOPNOTCH)

7

Agonist at the 5HT1D receptor in the blood vessels causing vasocontriction ; 1st line treatment for Acute migraine and cluster headache attacks

5HT1D receptor agonist: Sumatriptan, Naratriptan, Almotriptan, Eletriptan, Frovatriptan, Rizatriptan, Zolmitriptan (TOPNOTCH)

8

Selectively block 5HT3 receptors ; For antiemesis in patients post-chemotherapy or post-operation

5HT3 receptor antagonist: Ondansetron, Granisetron, Dolasetron, Alosetron (TOPNOTCH)

9

can inc QRS and QT (proarrhythmic effect) duration so never use in patients with heart disease

Dolasetron (TOPNOTCH)

10

SE: gangrene (sec to Ischemia) in overdose, unusual hyperplasia of the retroperitoneal, retropleural or subendocardial cavity --> hydronephrosis, cardiac valvular and conduction system malfunction

Ergotamine (TOPNOTCH)

11

uterus becomes more sensitive to ergots during pregnancy, produce very powerful and long-lasting contraction leading to decreased bleeding, Never give before delivery of placenta

Ergonovine (TOPNOTCH)

12

PGE1 analogue, causes increased HCO3 and mucus secretion in stomach and uterine contraction

Misoprostol, Gemeprost (TOPNOTCH)

13

may also be used together with Mifepristone or Methotrexate as safe abortifacient

Misoprostol (TOPNOTCH)

14

Low concentrations contract, higher concentrations relax uterine and cervical smooth muscle, soften cervix at term before induction with oxytocin

Dinoprostone, Sulprostone (TOPNOTCH)

15

PGF2a analogue, increases outflow of aqueous humor thus reduces intraocular pressure; For glaucoma

Prostaglandin F2a analog: Latanoprost, Arboprost, Bimatoprost, Travoprost, Unoprostone (TOPNOTCH)

16

used primarily for pulmonary hypertension

Prostaglandin I2 analog: Epoprostenol, Beraprost, Iloprost, Treprostinil (TOPNOTCH)

17

SE: Tachycadia, Nervousness, tremors, restlessness, arrythmias when used excessively, loss of responsiveness (tolerance, tachyphylaxis)

Beta2-selective agonist (short-acting): Albuterol/Salbutamol, Levalbuterol, Terbutaline, Metaproterenol, Pirbuterol, Procaterol, Fenoterol (TOPNOTCH)

18

Increase asthma mortality when used alone; May precipitate arrhytmias; usual DOA: 12hrs

Beta2-selective agonist (long acting): Salmeterol, Formoterol, Cleneterol, Bambuterol (TOPNOTCH)

19

More effective and less toxic than beta agonists ith COPD

Muscarinic receptor antagonist: Ipratropium, Tiotropium (TOPNOTCH)

20

Phosphodiesterase inhibitor, Adenosine receptor antagonist, causes bronchodilation and inc. strength of contraction of diaphragm; For asthma esp in nocturnal attacks

Methylxanthines: Theophylline, Aminophylline, Pentoxifylline (TOPNOTCH)

21

Antidote in overdosage is BB. Higher clearance in adolescents and smokers. Narrow therapeutic window

Methylxanthines: Theophylline, Aminophylline, Pentoxifylline (TOPNOTCH)

22

Prevents calcium influx and stabilizes mast cells, preventing degranulation and release of histamine, leukotrienes and mediators; for Asthma prophylaxis and allergies

Mast cell Stabilizer: Cromolyn, Nedocromil, Lodoxamide (TOPNOTCH)

23

DOC for Asthma prophylaxis, First line treatment for moderate to severe BA, COPD

Corticosteroid: Fluticasone, Beclomethasone, Budesonide, Flunisolide, Mometasone, Triamcinolone, Ciclosenide (TOPNOTCH)

24

For status asthmaticus

use IV prednisolone or hydrocortisone (TOPNOTCH)

25

active metabolite of prednisone

prednisolone (TOPNOTCH)

26

Inhibitor of 5-lipoxygenase. Reduces synthesis of leukotrienes. Prevents airway inflammation and bronchoconstriction; For asthma prophylaxis

Zileuton (TOPNOTCH)

27

No bronchodilator action, not recommended for acute BA attack

Zileuton, Montelukast, Zafirlukast, Pranlukast (TOPNOTCH)

28

Binds IgE antibodies on sensitized mast cells and prevents activation by BA triggers and subsequent release of inflammatory mediators; For prophylaxis of severe, refractory asthma not responsive to all other drugs

Anti-IgE antibody: Omalizumab (TOPNOTCH)