IL2 or IL6 Receptor Antagonist

Question 0

Tocilizumab

Answer 0

Actemra
Binds to IL6 receptor and competitive inhibits
6

Question 1

Anakira

Answer 1

Kineret
Blocks IL6 by competitive inhibition
Blocks pain, degradation and bone resorption

Question 2

Abatacept

Answer 2

Orencia
Fusion: CTLA4 and Fc
Fc binds to CD28 and blocks interaction with T cell
MHC thinks it is self and initiates T cell anergy

Anti-Costimulation

Question 3

Rituximab

Answer 3

Rituxan
Binds to B cell CD20 and blocks
Decreases B cells as APC, secreted cytokines, rheumatoid factor
AntiCD20

Question 4

AntiCD20

Answer 4

Ofatumumab

Ocrelizumab