What are the two types of defense systems?
Innate
Adaptive
What is part of the innate immune system?
Macrophage
Natural killer cell
Neutrophil
What types of WBC’s are in the adaptive immune system?
B cell
T cell
What is the 1st line of defense of the immune system?
3 components of internal (2nd line of defense)
What does a penetrated barrier do?
release of phagocytic cells (WBCs from bone marrow)
Neutrophils
devour and self-destruct
Macrophages
What do Natural Killer Cells do?
- Patrol blood and lymph looking for abnormal cells
What does barrier disruption cue?
inflammatory response
Learned Immunity
Acquired through differentiating friend from foe
Antigens
Large signaling molecules not normally found in the body
Adaptive vs. Innate
Adaptive takes more time to recruit
Systemic action
Humoral immunity –> B cells (antibodies
Cellular defenses –> T cells
B cell
Lymphocyte produced and matured in bone marrow
Ability to remember friend from foe
Patrol body’s humors (blood and lymph) inactively until antigen comes along
Immunocompetence
recognition and binding to a particular antigen
Self-tolerance
learning to not attack own cells
Organic pathogen introduction
- Ready-made maternal antibodies via passive humoral immunity
Artificial pathogen introduction
Pathogens from vaccinations
- introduce dead, weakened, or detoxified pathogens
T cells
- Fight body cells that have been hijacked by viruses/bacteria
Types of T cells
Helper T
Cytotoxic
Helper T cell
Signaler
Cytotoxic
Killer
T cell function