Flashcards in Immunity & Antibodies Deck (17):
What's the difference between naturally acquired and artificially acquired active immunity? (2)
1. Naturally acquired = during infection
2. Artificially acquired = received from vaccines
What is the part in vaccines that helps give us immunity and how? (2)
1. Vaccines “prime” the immune system with weakened antigens
2. Still able to stimulate antibody production
What do vaccines spare us from compared to naturally acquired immunity?
Spare us from the signs and symptoms of the disease that would otherwise occur during primary response
Define: passive immunity
Immunity acquired through antibodies that are obtained by human or animal donor (eg. fetus)
Where do immunogloblins come from? (2)
1. Secreted by activated B cells
2. Plasma offspring in response to an antigen
Describe the structure of an antibody. (3)
1. Consists of 4 amino acid chains linked together by disulfide bonds
2. Each chain has a variable region (V) at one end
3. Each chain has a constant region at the other end
What's the difference between the V region and C region? (2)
1. V = forms an antigen-binding site to fit specific antigens
2. C = determines the type of antibody that will be formed
List the 5 antibody classes. (5)
Which antibodies are monomers and what makes them monomers? (2)
1. IgD, IgG, and IgE
2. They have the same basic V shape structure = monomers
Which antibody is the most abundant in the blood plasma?
What is special about IgG?
It is the only antibody that can cross the placenta barrier (passive process)
What does IgE trigger?
Does IgA occur as monomers or dimers?
What is a dimer?
2 linked monomers
Where is IgA found and why? (2)
1. Found in the mucous and secretions (secretory)
2. Prevents pathogen entry
How many monomers is IgM composed of and what is this called? (2)
1. IgM is a huge, 5-linked monomer