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Flashcards in Immuno 1 Deck (27)
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1

acute inflammation

reaction peaks 48-72 hours after injury
Rubor, calor, tumor, dolor
activation of neutrophils

2

Chronic inflammation

Evolves over a long time (days to weeks)
Characterized by the presence of lymphocytes, macrophages, and plasma cells.
Tissue repair
Cell-derived & Plasma protein-derived inflammatory mediators

3

Cell-derived & Plasma protein-derived inflammatory mediators associated with chronic inflammation

Vasoactive amines, arachidonic acid metabolites, cytokines, ROS, NO, lysosomal enzymes
Complement proteins, coagulation proteins, kinins

4

Neutrophils derived from

myeloid precursor

5

Usually is the first inflammatory cell involved in the inflammatory response

Neutrophils

6

Eosinophils derived from

myeloid progenitors

7

Eosinophils

Respond to parasitic infection
Participate in allergic reactions in part through Fc receptors for IgE on their surface
Activity modulated by IL-5

8

Basophils and mast cells derived from

myeloid progenitors

9

Basophils

Granules contain histamine and serotonin
Called mast cells when found in tissue

10

Excessive mast cell degranulation can lead to

anaphylactic shock

11

mast cells can produce

prostaglandins and leukotrienes

12

Macrophages are activated by

IL-13

13

Macrophages are called ______ when present in

Called histiocytes when present in tissue where they clear out debris and converted to histiocytes by IFN-γ

14

Macrophages

Mediate the inflammatory response by secreting IL-1 and TNF-B which also produce fever
-Are APC cells

15

INNATE IMMUNITY

Neutrophils, macrophages & NK cells

16

ADAPTIVE IMMUNITY

Humoral (B lymphocyte) & cell (T lymphocyte) immunity
Requires antigen-specific molecules
More effective killing than innate immunity
Requires priming

17

B- Lymphocytes derived from

lymphoid progenitor cells; Bone marrow-derived

18

IgM coupled with signaling molecules =

BCR

19

___ coats (opsonizes) microbes, targets for phagocytosis; crosses placenta to promote passive immunity

IgG

20

activate complement system

IgG & IgM

21

in mucosal secretions

IgA

22

on tissue mast cells

IgE

23

on surface of B cells, but is not secreted

IgD

24

Expression of CD4+ or D8+ recognized antigens bound by ______, respectively

MHC class II or I

25

Expression of CD4+ or D8+ comprise ________, respectively

T-helper cells or cytotoxic T-cells

26

Helper T cells are either ___ (secrete IL-2, IFN-γ) or ___ (secrete IL4, IL-5, IL-13)

TH1; TH2

27

NK cells are either

CD8- or CD4-