Flashcards in Immuno 3: Part 1 Deck (30):
What is the alternative name for the Major Histocompatibility Complex for humans?
What is the alternative name for the Major Histocompatibility Complex for mice.
On which cell types are MHC II product being expressed?
On which cell types are MHC I products expressed?
Which 3 main regions in humans are MHC I genes found?
Which 3 main regions in humans are MHC II genes found?
How many classes comprise the mouse MHC complex?
Why do MHC genes get transmitted predominately as a package?
What type of expression do MHC alleles exhibit?
Which 2 molecules make up the MHC molecule?
B-2 microglobulin and a-chain
What is the function of B2 microglobulin?
Allows for stronger interaction between CD8 and MHC 1 molecule.
Which CTL surface molecule interacts with a3 domain of the MHC 1 molecule?
What is the typical size of peptide the MHC 1 molecule can bind to?
9 amino acids
Which domains of the MHC II molecule does the CD4 molecule bind to?
A2 and B2
What is the approximate location of the amino acids on a peptide that play an important role in binding to the MHC 1 molecule?
What is the typical size of a peptide that binds the MHC II molecule?
None of the above (real answer 13-18)
Which cytokine are known to up-regulate expression of MHC molecules ?
Which cell type participate in cell mediated immune response and is antigen specific?
???? ( answer would be Tc or Th (DTH))
Which cell type participates in cell mediated immune response and is NOT antigen specific?
Individuals with Digeorge Syndrome
Can address extracellular bacterial infections effectively.
CD4+ cells do not play a significant role in cell mediated immune system responses
The CD45 RA surface marker is expressed on a naive T cell.
The LFA-1 surface markets binds ICAMS molecules
FasL is expressed on naive T cells
The major source of IL-2 during CTL-P activation is TB2
CD28 and B7 interaction results in co-stimulation
Tetramer technology allows detection of activated Macrophages?
False (because it shouldn't have said Macrophages but it should have been CTL for it to be true)
During acute VSV infection large numbers of antigens specific CTLs have been shown to localize in the liver.
Activation of LFA-1 occurs during conjugate formation