Immuno 3: Part 1 Flashcards Preview

IMMUNO EXAM 3 > Immuno 3: Part 1 > Flashcards

Flashcards in Immuno 3: Part 1 Deck (30):
1

What is the alternative name for the Major Histocompatibility Complex for humans?

HLA

2

What is the alternative name for the Major Histocompatibility Complex for mice.

H-2

3

On which cell types are MHC II product being expressed?

Dendritic cells

4

On which cell types are MHC I products expressed?

T-cells ???????

5

Which 3 main regions in humans are MHC I genes found?

A,B,C

6

Which 3 main regions in humans are MHC II genes found?

DP,DQ,DR

7

How many classes comprise the mouse MHC complex?

2 ???????

8

Why do MHC genes get transmitted predominately as a package?

???????

9

What type of expression do MHC alleles exhibit?

Co-dominance

10

Which 2 molecules make up the MHC molecule?

B-2 microglobulin and a-chain

11

What is the function of B2 microglobulin?

Allows for stronger interaction between CD8 and MHC 1 molecule.

12

Which CTL surface molecule interacts with a3 domain of the MHC 1 molecule?

CD8

13

What is the typical size of peptide the MHC 1 molecule can bind to?

9 amino acids

14

Which domains of the MHC II molecule does the CD4 molecule bind to?

A2 and B2

15

What is the approximate location of the amino acids on a peptide that play an important role in binding to the MHC 1 molecule?

Position 2

16

What is the typical size of a peptide that binds the MHC II molecule?

None of the above (real answer 13-18)

17

Which cytokine are known to up-regulate expression of MHC molecules ?

IFN-y

18

Which cell type participate in cell mediated immune response and is antigen specific?

???? ( answer would be Tc or Th (DTH))

19

Which cell type participates in cell mediated immune response and is NOT antigen specific?

Macrophage

20

Individuals with Digeorge Syndrome

Can address extracellular bacterial infections effectively.

21

CD4+ cells do not play a significant role in cell mediated immune system responses

False

22

The CD45 RA surface marker is expressed on a naive T cell.

True

23

The LFA-1 surface markets binds ICAMS molecules

True

24

FasL is expressed on naive T cells

False

25

The major source of IL-2 during CTL-P activation is TB2

False

26

CD28 and B7 interaction results in co-stimulation

True

27

Tetramer technology allows detection of activated Macrophages?

False (because it shouldn't have said Macrophages but it should have been CTL for it to be true)

28

During acute VSV infection large numbers of antigens specific CTLs have been shown to localize in the liver.

True

29

Activation of LFA-1 occurs during conjugate formation

True

30

Antibody dependent cell mediated cytotoxicity is mediated to FcR

True