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Flashcards in Immuno & Micro Deck (26):
1

These vessels in the paracortex of lymph nodes allow T and B cells to enter the node from the blood

High endothelial venules

2

This part of the lymph node enlarges in an extreme immune response

Paracortex

3

Lymph from the lateral dorsum of the foot drains first to the _____

Popliteal nodes

4

Drains the right arm and right half of the head

Right lymphatic duct

5

Drains everything except the right arm and right side of the head

Thoracic duct

6

Macrophages in the spleen remove ______________ bacteria

Encapsulated bacteria

- Salmonella
- S. pneumonia
- H. Flu
- N. meningitidis

7

MHC 1 is found on which cells?

All nucleated cells

- not on RBCs

8

-MHC that mediates viral immunity
- pairs with beta 2 microglobulin
-binds CD8

MHC 1

9

-MHC that is expressed only on antigen presenting cells
- mediates bacterial infections
- antigens loaded following release of invariant chain in the endosome
- binds CD4

MHC II

10

Diseases associated with HLA B27

"PAIR"

Psoriasis
Ankylosing Spondylitis
Inflammatory bowel dz
Reiter's syndrome

11

HLA associated with Hemochromatosis

HLA A3

12

HLA associated with Graves' disease

HLA B8

13

HLA associated with MS, hay fever, Lupus, & Goodpastures

HLA DR2

14

HLA associated with DM 1

HLA DR3

15

HLA associated with Rheumatoid arthritis and DM 1

HLA DR4

16

HLA associated with pernicious anemia (B12 deficiency caused by autoimmune gastritis) & HASHIMOTOS thyroiditis

HLA DR5

17

-These cells are enhanced by IL-12, IFN-beta & IFN- alpha
- they use perforin & granzyme to kill virally infected and tumor cells

NK Cells

18

Antibodies that can fix complement

IgG & IgM

"GM makes classic cars"

- IgG and IgM start the "classic" complement pathway

19

IgE binds mast cells and basophils & crosslinks free antigen / allergens in type ______________ hypersensitivity rxns

Type 1 ( immediate)

20

What activates the alternate complement pathway

Microbial surfaces

21

Neutrophils are called by IL-______

IL-8 ("clean up on aisle 8")

22

IL-_____ promotes class switching to IgA

IL-5

23

Which infections can you give antitoxin to counteract and give passive immunity ?

"To Be Healed Rapidly"

Tetanus
Botulinum
Hepatitis B
Rabies

24

IL-12 receptor deficiency causes

Decreased Th1 response, disseminated mycobacterial infections

25

Microtubule dysfunction in phagosome- lysosome fusion, recurrent pyogenic infections, partial albinism, peripheral neuropathy

Chediak- Higashi syndrome

26

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