Immuno Drugs Flashcards Preview

USMLE Step 1 > Immuno Drugs > Flashcards

Flashcards in Immuno Drugs Deck (28):
1

Cyclosporine: Mechanism

Calcineurin inhibitor
- binds to cyclophillins
- complex blocks differentiation and activation of T cells by inhibiting calcineurin thus NO IL-2 and IL-2 receptor production

2

Cyclosporine: Use

Suppresses organ rejection after transplantation; selected autoimmune disorders

3

Cyclosporine: Toxicity

Nephrotoxicity, Hypertension, Hyperlipidemia, Hyperglycemia, Tremor, Gingival hyperplasia

4

Tacrolimus

- Calcineurin inhibitor, binds to FK- binding protein
- inhibits secretion of IL-2
- potent immunosuppressive and used in organ transplant recipients

5

Tacrolimus Toxicity

HYPERlipidemia, HYPERglycemia, Tremor, HTN, Nephrotoxicity

6

Sirolimus (Rapamyocin)

inhibits mTOR. Inhibits T-cell proliferation in response to IL-2
- immunosuppression after kidney transplant in combo with cyclosporine and corticosteroids
- used with drug-eluting stents

7

Sirolimus: Toxicity

Hyperlipidemia, Thrombocytopenia, Leukopenia

8

Azathioprine

antimetabolite precursor of 6-MP that interfers with metabolism and synthesis of nucleic acids. Toxic to proliferating lymphocytes
- used for kidney transplants, autoimmune disorders (glomerulonephritis and hemoluytic anemia)

9

Azathiprine Toxicity

Bone marrow suppression. Active metabolite mercaptopurine can be metabolized by xanthine oxidase.
Toxic effects may be increased by allopurinol

10

Muromonab-CD3 (OKT3)

- monoclonal antibody that binds to CD3 on surface of T cells. Blocks interaction with CD3 protein responsible for T-cell signal transduction
- immunosuppression after kidney transplant

11

Muromonab-CD3 (OKT3) Toxicity

Cytokine release syndrome
Hypersensitivity reaction

12

Aldesleukin

IL-2 - used for renal cell carcinoma, metastatic melanoma

13

Epoetin alfa (

Erythropoitein - used for anemia

14

Filgrastim

G-CSF - used to recovery bone marrow

15

Sargramostim

GM-CSF - used to recover bone marrow

16

Alpha interferon

Used for Hep B and C
Kaposi's sarcoma
Leukemias
Malignant melanoma

17

B-interferon

Multiple sclerosis

18

Gamma-interferon

Chronic granulomatous fisease

19

Oprelvekin

IL -11 - used for Thrombocytopenia

20

Thrombopoetin

Thrombocytopenia

21

Muromonab-CD3 (OKT3)

- targets CD3
- used to prevent ACUTE transplant rejection

22

Digoxin Immune Fab

- targets Digozin
- antidode for digoxin intoxication

23

Infliximab

- target TNF-alpha
- antidote for Crohn's disease, RA, Psoriatic arthritis, Ankylosing spondylitis

24

Adalmimumab

- targets TNF-alpha
- Crohn's disease, RA, psoriatic arthritis

25

Abciximab

- targets Glycoprotein IIB/IIa
- prevent cardiac ischemia in unstable angina and in patients treated with percutaneous coronary intervention

26

Trastuzumab (Herceptin)

- targets HER2
- HER-2 overexpressing breast cancer

27

Rituximab

- targets CD20
- used for B-cell non-Hodgkin's lymphoma

28

Omalizumab

- targets IgE
- additional line of treatment for severe asthma