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Flashcards in Immuno Midterm 1 Deck (20):
1

second child, miscarriage: pathophysiologic mechanism?

Fetal anemia caused by preformed maternal IgG to fetus' blood type

2

unilateral ptosis, ispilateral extraocular muscle weakness, edrophonium test: pos; what is HSR?

Type II (graves DZ)

3

Ankylosing spondylitis, Reiter syndrome, acute anterior uveitis positive for HLA:

HLA B27

4

hyperthyroidism (graves dz) associated with HLA:

HLA B8

5

psoriasis vulgaris is associated with HLA:

HLA-Cw6

6

HLA associated with rheumatoid arthritis and DM type 1

HLA-DR4

7

HLA associated with Goodpasture syndrome, MS, SLE

HLA-DR2

8

recurrent pneumococcal pnuemonia, healthy until 6 months, recurrent ear infections, abscesses; underlying condition?

Mutation in tyrosine kinase (BTK gene); Bruton's agammaglobulinemia

9

SLE, blood in urine; what autoantibody associated with severity of renal dz

anti-DsDNA antibody

10

autoantibody found in drug induced lupus

anti-histone antibody

11

Anti-Jo-1 antibody associated with?

polymyostitis, dermatomyostitis,

12

antibody associated with lupus anticoagulant

anti-phospholipid antibody

13

biliary cirrhosis is associate with what antibody

anti-mitochondrial

14

recurrent pneumonia, severe persistant diarrhea, elevated IgM: analysis of peripheral leukocytes show what?

an absent ligand (CD40L) that is important for T-cell activation and induction of class switching in B-cells

15

HX: listeria pneumoniae, ecoli UTI, blood culture: S. aureus: what assay would be abnormal?

DHR assay (decrease in green fluorescence) BC chronic granulomatous dz

16

recurrent nosebleeds, multiple URI and ear infections, dry scaly rash: DDX?

Wiskott Aldrich syndrome

17

rash from belly piercing 3 days ago what HSR?

IV (delayed response, cell mediated)

18

Raynauds, telangiectasia, erosive polyarthritis, proteinuria, membranous glomerulonephritis, POSITIVE U1-RNP: DDX?

Mixed connective tissue disorder

19

URI, nasal crusting, epitaxis, elevated Cr, what antibody is associated

c-ANCA (granulomatosis with polyangitis)

20

test correlates best with SLE activity when there is a flare, esp nephritis or vasculitis

anti-double stranded DNA