Flashcards in Immuno midterm 2 Deck (27):
hemoptysis, elevated blood urea and creatinine, antiglomerular basement membrane antibody; what HSR/dz
Goodpasture syndrome; type II HSR
butterfly rash on face, elevated antinuclear antibody titer; auto antibodies?`
anti-dsDNA antibody (SLE)
pseudomonal pneumonia, multiple staph skin and soft tissue infections, culture positive for aspergillus, serratia, nocardia (catalase positive); what is defective?
adenine dinucleotide phosphate oxidase (NADPH oxidase); has chronic granulomatous dz
newborn: hepatospenomegaly, jaudice, pallor, not prenatal appt, what type HSR
Type II HSR (Rh- mom and Rh+ kid
mid 20s male, progressive renal failure, cough, dyspnea, patchy shadowing of both lungs, hymoptysis; IgG against glomular basement membrane; DDX?",
number of IL-18 positve macrophages, leukopenia in Sjoren's syndrome indicates?"
Lymphoma (correlates with degree of parotid enlargement)
low levels of C4 predict what?
bone pain, anemia, renal dysfunction, elevated erythrocyte sedimentation rate, urinalysis: Bence Jones proteins; electo: spike in gamma-globulin fxn: DDX?
"baby with recurrent pneumonida, otitis media, skin infections, B and T cell deminished, lyphopenia, myphocytes don’t respond to mitogens; DDX?",
"young male w/ low back pain of sacroiliac joint and spine, Xrays: bilateral sacroilitis; which HLA subtype associated with dz?",
HLA-B27 (ankylosing spondylitis (AS)
"well circumscribed raised skin, silvery scales; which HLA associated w/ dz"
(HLA-CW6) psoriasis vulgaris
"bullae in skin and oral mucosa, shallow erosion w/ dried skin (Nikolsky sign) what HLA associated w/dz",
HLA-DQ1 (pemphigus vulgaris)
"HLA associated with Sjogren syndrome, SLE, chronic active hepititis, dermatitis herpetiformis
"HLA associated with rheumatid arthitis, pemphigus vulgaris, addison dz, and type 1 DM",
"received bone marrow transplant, dyspea, dry cough, wheezes expiratory high pitch sounds, obstructive picture on spirometry: DDX?"
"HLA associated with dry eyes, heart racing, weight loss, proptosis, smooth goiter
HLA-DR3 and HLA-B8 (Graves dz)
HLA(s) associated with celiac dz
HLA associated with pernicious anemia and chronic lymphocytic thyroiditis (Hashimotos thyroiditis),
"upper lung lobe cavitary lesion in african, chronic cough, hemotysis, wt loss, night sweats: type of HSR?"
type IV HSR (TB=granuloma formation which is IV)
"1-6 hours after blood transfusion, fever, chills, headache, back pain: what mechanism responsible"
antibodies to WBC HLA from compatible donor
"patchy hypopigmentation of skin, hypopigmented hair, lymphocytes large with round reddish colored inclusion body, large platelets: underlying cause of defects?
microtubule dysfunction and lysosomal release (Chediak Higashi)
"red hair, abscess formation, retension baby teeth, eczema: underlying cause of defects",
Failure of IFN-gamma production (hyper IgE)
"lesions of central discoloration surrounded by concentric rings and contain vesicles or bullae on palms, soles, face: what type of HSR",
Type IV (erythema multiform)
"fever, night sweats, weight loss, cough with hemoptysis in military personnel: type of HSR",
Type IV (TB)
swelling of mucosal surfaces, abd pain, diarrhea, no response to epi or antihistmine, father and grandfather have similar symptoms: what is decreased in blood?
levels of C4, C3, C1 (hereditary angioedema)
causitive defect of leukocyte adhesion deficiency type 1 ,