Immuno midterm 2 Flashcards Preview

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Flashcards in Immuno midterm 2 Deck (27):
1

hemoptysis, elevated blood urea and creatinine, antiglomerular basement membrane antibody; what HSR/dz

Goodpasture syndrome; type II HSR

2

butterfly rash on face, elevated antinuclear antibody titer; auto antibodies?`

anti-dsDNA antibody (SLE)

3

pseudomonal pneumonia, multiple staph skin and soft tissue infections, culture positive for aspergillus, serratia, nocardia (catalase positive); what is defective?

adenine dinucleotide phosphate oxidase (NADPH oxidase); has chronic granulomatous dz

4

newborn: hepatospenomegaly, jaudice, pallor, not prenatal appt, what type HSR

Type II HSR (Rh- mom and Rh+ kid

5

mid 20s male, progressive renal failure, cough, dyspnea, patchy shadowing of both lungs, hymoptysis; IgG against glomular basement membrane; DDX?",

Goodpasture syndrome;

6

number of IL-18 positve macrophages, leukopenia in Sjoren's syndrome indicates?"

Lymphoma (correlates with degree of parotid enlargement)

7

low levels of C4 predict what?

lymphoma

8

bone pain, anemia, renal dysfunction, elevated erythrocyte sedimentation rate, urinalysis: Bence Jones proteins; electo: spike in gamma-globulin fxn: DDX?

multiple myeloma

9

"baby with recurrent pneumonida, otitis media, skin infections, B and T cell deminished, lyphopenia, myphocytes don’t respond to mitogens; DDX?",

SCID

10

"young male w/ low back pain of sacroiliac joint and spine, Xrays: bilateral sacroilitis; which HLA subtype associated with dz?",

HLA-B27 (ankylosing spondylitis (AS)

11

"well circumscribed raised skin, silvery scales; which HLA associated w/ dz"

(HLA-CW6) psoriasis vulgaris

12

"bullae in skin and oral mucosa, shallow erosion w/ dried skin (Nikolsky sign) what HLA associated w/dz",

HLA-DQ1 (pemphigus vulgaris)

13

"HLA associated with Sjogren syndrome, SLE, chronic active hepititis, dermatitis herpetiformis

HLA-DR3

14

"HLA associated with rheumatid arthitis, pemphigus vulgaris, addison dz, and type 1 DM",

HLA-DR4

15

"received bone marrow transplant, dyspea, dry cough, wheezes expiratory high pitch sounds, obstructive picture on spirometry: DDX?"

bronchiolitis obliterans

16

"HLA associated with dry eyes, heart racing, weight loss, proptosis, smooth goiter

HLA-DR3 and HLA-B8 (Graves dz)

17

HLA(s) associated with celiac dz

HLA-DQ2/DQ8

18

HLA associated with pernicious anemia and chronic lymphocytic thyroiditis (Hashimotos thyroiditis),

HLA-DR5

19

"upper lung lobe cavitary lesion in african, chronic cough, hemotysis, wt loss, night sweats: type of HSR?"

type IV HSR (TB=granuloma formation which is IV)

20

"1-6 hours after blood transfusion, fever, chills, headache, back pain: what mechanism responsible"

antibodies to WBC HLA from compatible donor

21

"patchy hypopigmentation of skin, hypopigmented hair, lymphocytes large with round reddish colored inclusion body, large platelets: underlying cause of defects?

microtubule dysfunction and lysosomal release (Chediak Higashi)

22

"red hair, abscess formation, retension baby teeth, eczema: underlying cause of defects",

Failure of IFN-gamma production (hyper IgE)

23

"lesions of central discoloration surrounded by concentric rings and contain vesicles or bullae on palms, soles, face: what type of HSR",

Type IV (erythema multiform)

24

"fever, night sweats, weight loss, cough with hemoptysis in military personnel: type of HSR",

Type IV (TB)

25

swelling of mucosal surfaces, abd pain, diarrhea, no response to epi or antihistmine, father and grandfather have similar symptoms: what is decreased in blood?

levels of C4, C3, C1 (hereditary angioedema)

26

causitive defect of leukocyte adhesion deficiency type 1 ,

integrin (CD18)

27

causitive defect of leukocyte adhesion deficiency type 2,

selectin (CD15)