Flashcards in Immuno midterm 3 Deck (22):
proximal interphalangeal and metacarpophalangeal joints have hands: what is most specific blood test for dz?
18yr college student, petechial rash, gram-neg diplococci that ferment maltose. What immunodeficiency does he most likely have?
C8 deficiency (this def is increased risk for N. meningitis)
complement deficiency leads to recurrent infections of?
encapsulated organisms (ie n. meningitidis, strep pneumoniae, haemophilus influenzae
which interferon causes hemolysis, metallic taste, insomnia, fatigue and which one causes seizures, hypothyroidism
alpha-interferon causes hemolysis, metallic taste, insomnia, fatigue
beta causes seizures, hypothyroidism
right upper quadrant pain, recurrent bloody BM, superficial colorectal mucous ulceration and inflammation with many pseudopolyps, liver enlarged and tender: what auto-antibody positive in pt?
p-ANCA (ulcerative colitis and/or PSC)
allergic contact dermatitis is what type HSR
70yr male lost weight, mild splenomegaly, not feeling right, blood smear=lysed cells: what is pathology?
Excess CD5+, CD23+ cells (CLL/SLL which is a B-cell leukemia)
CD16+, CD56+, CD3-, CD5- what cell?
CD19, CD20, CD23 what cell?
CD3+, CD4+, CD5+ what cell?
CD14+ what cell
recieves blood transfusion, during transfusion fever, loin pain, and hypotension, positive coombs test; what HSR
fever, chills, nausea 4 hours after transfusion; what is cause of this?
Pt's anti-HLA antibody reacting with donor's WBC
4 days after transfusion: fever, centrifugally spreading rash which becomes erythrpderma with Bullae, lymphadenopathy, pancytopenia, jaundice, elevated liver enzymes, watery diarrhea. What is cause?
Graft vs host dz
eyes "feel heavy", blurry vision, hard to read, what type HSR?
Type II (Myasthenia gravis)
which cytokine inhibits TH-2 cells and stimulates macrophages; important in granulomatous inflammation
interferon-gamma is secreted by?
NK cells and T-cell
Which IL promotes growth of B cells, IgE class switching, and differentiation of B-cells to plasma cells
Which ILs are secreted by TH-2 cells
IL-4, 5, 6
Which IL promotes differentiation of B cells and activation of Eosinophils
Which IL stimulates immunoglobin and acute phase reactant production, pro-inflammatory