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Flashcards in Immuno midterm 3 Deck (22):
1

proximal interphalangeal and metacarpophalangeal joints have hands: what is most specific blood test for dz?

Anti-CCP (RA)

2

18yr college student, petechial rash, gram-neg diplococci that ferment maltose. What immunodeficiency does he most likely have?

C8 deficiency (this def is increased risk for N. meningitis)

3

complement deficiency leads to recurrent infections of?

encapsulated organisms (ie n. meningitidis, strep pneumoniae, haemophilus influenzae

4

which interferon causes hemolysis, metallic taste, insomnia, fatigue and which one causes seizures, hypothyroidism

alpha-interferon causes hemolysis, metallic taste, insomnia, fatigue

beta causes seizures, hypothyroidism

5

right upper quadrant pain, recurrent bloody BM, superficial colorectal mucous ulceration and inflammation with many pseudopolyps, liver enlarged and tender: what auto-antibody positive in pt?

p-ANCA (ulcerative colitis and/or PSC)

6

allergic contact dermatitis is what type HSR

IV HSR

7

70yr male lost weight, mild splenomegaly, not feeling right, blood smear=lysed cells: what is pathology?

Excess CD5+, CD23+ cells (CLL/SLL which is a B-cell leukemia)

8

CD16+, CD56+, CD3-, CD5- what cell?

NK cells

9

CD19, CD20, CD23 what cell?

B-cells

10

CD3+, CD4+, CD5+ what cell?

Helper T-cells

11

CD14+ what cell

macrophages

12

recieves blood transfusion, during transfusion fever, loin pain, and hypotension, positive coombs test; what HSR

Type II

13

fever, chills, nausea 4 hours after transfusion; what is cause of this?

Pt's anti-HLA antibody reacting with donor's WBC

14

4 days after transfusion: fever, centrifugally spreading rash which becomes erythrpderma with Bullae, lymphadenopathy, pancytopenia, jaundice, elevated liver enzymes, watery diarrhea. What is cause?

Graft vs host dz

15

eyes "feel heavy", blurry vision, hard to read, what type HSR?

Type II (Myasthenia gravis)

16

which cytokine inhibits TH-2 cells and stimulates macrophages; important in granulomatous inflammation

Interferon-gamma

17

interferon-gamma is secreted by?

NK cells and T-cell

18

Which IL promotes growth of B cells, IgE class switching, and differentiation of B-cells to plasma cells

IL-4

19

Which ILs are secreted by TH-2 cells

IL-4, 5, 6

20

Which IL promotes differentiation of B cells and activation of Eosinophils

IL-5

21

Which IL stimulates immunoglobin and acute phase reactant production, pro-inflammatory

IL-6

22

Tumor necrosis factor is manufactured by?

macrophages