Immunodeficiency & Immunosuppression (33) Flashcards
Dr. Phillips
What is immunodeficiency? It is [primary/secondary]
disease in which immune function is partially or totally absent
primary
What is immunosuppression? It is [primary/secondary]
inhibition of the immune system by an extraneous factor
secondary
Which immunodeficiency is inherited?
primary
What is primary immunodeficiency?
defects in mechanical barriers
defects in nonspecific defenses
defects in specific defenses
inherited!
What are findings that point to a primary immunodeficient state?
unexplained neonatal illness affecting more than one animal in a litter
illness due to commensal or low pathogenic organism
recurrent illness
disease from MLV
What are mechanical barrier defects illnesses?
immotile cilia syndrome
What is ciliary dyskinesia?
autosomal recessive disorder
dysplastic or immotile cilia to abnormalities in microtubule organization
signs include poor weight gain, coughing, nasal discharge, bronchopneumonia
mechanical defect
Immotile cilia syndrome manifests as a ______
recurrent respiratory tract infection
What is cyclic hematopoiesis of grey collies?
accompanied by dilution of skin/hair pigment
cyclic fluctuations in WBC #s
underlying defect not knows
disease is due primarily to decreased numbers and function in neutrophils
recurrent infections
acquired disease
non-specific immunologic defenses
What is chediak highashi syndrome?
non-specific immunologic defenses
autosomal recessive disease
What does Chediak haghashi syndrome affect?
granulocytes - abnormal lysosomes/granules, more fragile
defective chemotaxis, motility, delayed killing after phagocytosis
Nk cells also affected
recurrent infections
What is Pelger Huet anomaly?
paste picture later - wifi is being shitty
Pelger Huet anomaly is mistaken sometimes as ______
myeloid leukemia
What is canine granulocytopathy syndrome?
also called canine leukocyte adhesion deficiency
autosomal recessive trait describe in Irish Setters & Holsteins
neutrophils have defective respiratory burst - mutation in integrin and neutrophils can’t emigrate from blood vessels and unable to phagocytose bacteria coated with C3b
severe infections - skin, gingiva, etc
What are immunodeficiencies of weimaraners?
congenital with unknown heritability pattern
recurrent fevers, diarrhea, pneumonia, pyoderma, osteomyelitis
low levels of IgG, IgA, IgM
defective neutrophil function
may have adverse response to vaccination - don’t develop protective titers
