Immunoglobulins Flashcards Preview

SI > Immunoglobulins > Flashcards

Flashcards in Immunoglobulins Deck (21)
Loading flashcards...
1

IgD structure

Monomer

2

IgE structure

Monomer

3

IgG structure

Monomer

4

IgM structure

Pentamer with J chain

5

IgA subclasses

2 (a1, a2)

6

IgD subclasses

None

7

IgE subclasses

None

8

IgE subclasses

None

9

IgG subclasses

y1-4

10

IgM subclasses

None

11

IgA found in

Secretions (saliva, tears, breast milk)
Intestinal fluids
Serum

12

IgD found in

On surface of B cells

13

IgE found in

Blood

14

IgG found in

Blood: intravascular and extravascular spaces

15

IgM found in

Blood: intravascular spaces

16

IgA bio activity

In secretions it protects against foreign antigens

17

IgD bio activity

Basically unknown, but thought to play a role in antigen binding in association with IgM and B-cell activation

18

IgE bio activity

Binds to mast cells and basophils mediating release of histamine and heparin
Plays a role in helminth infections

19

IgG bio activity

Neutralize toxins, activates complement, crosses placenta, agglutination, opsonization

20

IgM bio activity

Complement activation and agglutination

21

IgA structure

Monomer and dimer with j chain