Immunology 1 Flashcards
give 2 examples of mechanical barriers
epithelial cells/cilia
tears
give 3 examples of chemical barriers
pH
enzymes
a/b defensins
what’s a zymogen
inactive form of an enzyme
activated by another enzyme
what’re some features of defensins (2)
amphipathic (hydrophobic & philic)
formes pores in membrane
what’re some features of cathelicidins (2)
amphipahthic (hydrophoibic/phillic)
formes pores in membrane
where are histains produced
major salivary glands
which cells are of the adaptive immune system
B&T lymphocytes
what’re the 3 ways to activation pathways of the complement system
alternative
- antibody forms spontaneously
classical
- antibody binds to receptor
lectin
- mannose binding lectin
what’re the functions of the complement system (3)
Amplify response
help facilitate recognition of bacteria by phagocytes
directly lyse bacteria
what’s the shared intermediate step of the complement system
use of C3b to form C3 convertase
what’re the 3 effector steps of the complement system
- what variation of C is present in each
opsonisation
- tag pathogens for phagocytosis
- C3b
anaphlatoxin production
- bring more cells to site & inflammation
- C3a & C5a
formation of MAC
- forms pores in plasma membrane
- C6-9
what’re the uses of:
- C3b
- C3a/C5a
- C6-9
- opsonisation & phagocytosis
- inflammation
- lysis of microbes
