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Year 2 - Ophthalmology (DP) > Immunology > Flashcards

Flashcards in Immunology Deck (23):
1

What microbes does lysozyme defend against?

Gram negatives
Fungi

2

What microbes do lactoferrin and transferrin defend against?

Grae positives

3

What do tear lipids do?

Antibacterial to cell membranes

4

What does secretory IgA in tears do?

Prevents microbial attachment

5

What does the mucous layer of tears do?

Acts as an antiadhesive

6

What role do tear neutrophils carry out?

Scavengers
Release free-radicals and enzymes

7

What do conjunctival mast cells do?

Vasoactive mediators

8

What is the only part of the eye with lymphatic drainage?

Conjunctiva

9

What cells act as APCs in the conjunctiva?

Dendritic cells

10

What lymphoid tissue is in the conjunctiva?

Mucosa-associated (MALT):
- Conjunctival-associated Lymphoid Tissue (CALT)

11

True or false; The conjunctiva is totally sterile?

False:
- It has commensal bacteria

12

True or false; The sclera and conjunctiva have rich blood supplies?

False:
- They are avascular

13

What sort of immune environment do the sclera and conjunctiva have?

Downregulated:
- Relative lack of APCs

14

What sort of immune environment do the vitreous, choroid and retina have?

Downregulated:
- Relative lack of APCs

15

Which of the following body areas cannot tolerate antigen introduction without eliciting inflammation:
- Brain/CNS
- Testes
- Heart
- Placenta/Foetus
- Eyes

Heart
Current evidence has shown that the brain and CNS do not have immune privilege

16

What factors contribute to the ocular immune privilege?

Blood barrier
Lack of direct lymphatic drainage
Rich in immunosuppressive molecules:
Placement of Ag into eye:
- Systemic form of tolerance to said AG
- Anterior Chamber-Associated Immune Deviation (ACAID)

17

What is sympathetic Ophthalmia?

Rare, bilateral, granulomatous uveitis due to:
- Trauma (most commonly)
- Surgery
-> To only one eye

18

What are the primary mediators of Sympathetic Ophthalmia thought to be?

T cells:
- Initial CD4+ infiltrate
- Later wave of CD8+

19

What are the terms given to the injured and the other eye in Sympathetic Ophthalmia?

Injured eye -> Exciting eye
Other eye -> Sympathising eye

20

What is an example of a Type I Hypersensitivity Reaction in the eye?

Acute allergic conjunctivitis

21

What is an example of a Type II Hypersensitivity Reaction in the eye?

Ocular cicatricial pemphigoid

22

What is an example of a Type III Hypersensitivity Reaction in the eye?

Autoimmune corneal melting

23

What is an example of a Type IV Hypersensitivity Reaction in the eye?

Corneal graft rejection