Immunology Flashcards
What is innate immune response?
fast and non specific
What is adaptive immune response?
slow and specific
What is the adaptive immune response mediated by? and what is it responsible for?
T and B lymphocytes
Generating immunulogical memory
What is the innate immune response mediated by?
PRR molecules which are PAMP receptors.
PAMPs are expressed on non human pathogen cells
Where do basophils mature?
bone marrow
Where do macrophages mature?
tissues
Name some pro-inflammatory cytokines
IFNg (macrophage activation)
TNFa
IL1
IL6
What are opsonins?
they enhance phagocytosis by marking an antigen for an immune response or marking dead cells for recycling
Where does CRP come from?
C reactive protein - marker for inflammation in the body
liver
What cells do MHC class 1 and HLA class 1 present to?
CD8 T cytotoxic cell
What cells do MHC class 2 and HLA class 2 present to?
CD4 T helper cell
Where is class 1 expressed?
all nucleated cells
Where is class 2 expressed?
only on dendritic cells, macrophages, B cells
What do B lymphocytes produce?
antibodies
What cells are involved in the innate immune response?
What are they responsible for?
o Mast cells o NK cells o Phagocytes o Complement Acute inflammation and killing of pathogen
What cells are phagocytes and what are their role?
Neutrophils monocytes macrophages dendritic cells Ingest and kill bacteria Important source of cytokines