Immunology--> cell markers, etc Flashcards Preview

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Flashcards in Immunology--> cell markers, etc Deck (15):
1

found on all T cells

1. CD3--> associated with TCR and necessary for signal transmission due to TCR binding
2. CD28 (binds B7)

2

4 molecules on APC cell surface

1. MHC I
2. MHC II
3. B7
4. CD40

3

what are B7 also called (CD... 2 numbers)

CD80 or CD86

4

function of CD40 on APC

allows T-cells to activate APC

5

3 types of cells with antigen presenting capacity

1. Dendritic cells--> in interstitium of all organs except brain
2. Langerhans cells (epidermal layers of skin)
3. B cells

6

pathology of Langerhans cell histiocytosis

hyperproliferation of non-functional alngerhans cells (from monocyte lineage); can't stimulate T-cells

7

symptoms of Langerhans cell histiocytosis

child with lytic bone lesions and rash

8

characterisistic EM finding in langerhans cell histiocytosis

Birbeck granules--> look like tennis rackets

9

what two abnormal proteins do defective cells in langerhans cell histiocytosis express

1. S-100 --. main one to know, is a nueral crest marker
2. CD1a

10

3 markers on T reg cells

1. CD3
2. CD4
3. CD25

11

2 markers on helper T cells

1. CD4
2. CD40-L (binds CD40 on B cells, like the B7-CD40 costimulation)

12

2 markers on NK cells

1. CD16
2. CD56 (unique T cell marker)

13

function of CD16

binds to constant region of Abs--> allows for Antibody-dependent Cell-mediated Cytotoxocity (ADCC)

*also found on neutrophils and some macrophages/monocytes

14

8 markers found on B cells

1. IgM
2. IgD
3. CD19
4. CD20
5. CD21
6. CD40
7. MHC II
8. B7 (CD80 or CD86)

15

6 cell surface proteins found on macrophages

1. CD14
2. CD40
3. MHC II
4. B7
5. Fc and C3b-> enhanced phagocytosis

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