Flashcards in Immunology Jeopardy Deck (33):
This is produced by bone marrow stromal cells to induce development and proliferation of B lineage.
This cell comes from a common lymphoid progenitor but is considered part of the innate immune response
NK cells/ ILCs
This cytosolic PRR cleaves IL-1 beta
The inflammasome NOD- Like receptors
The first cell that enters an inflamed tissue from the blood
Tissue macrophages are there first, but the first cell that comes from the blood stream are neutrophils, monocytes come after neutrophils and are more numerous when they respond.
The observation that a single antigen specific lymphocyte can undergo massive expansion/proliferation when binding specific antigen is a major tenent of the...
clonal expansion theory; (other tenets, non-reactivity to self, identical to parent cells, specific receptors
The most variable portion of the heavy and light chains are in this area of the amino acid sequence
What is the hyper variable region/CDR3
Viruses tend to induce the production of __________ after PRR engagement
Type I interferons ( include alpha and beta)
This molecule is an important opsonin in the innate immune response
Mannose binding lectin
What is an endocytic receptor?
Macrophage mannose receptor
What is a type of signaling receptors?
What are some examples of cytosolic receptors?
RIG-1, NOD like receptor, MDA-5,
___________ and __________ are adhesion molecules that participate in in tight binding of neutrophils to endothelium
LFA-1 (Neutrophil) ICAM-1 (Endothelium)
This process occurs in the heavy chain locus during the Pro-B cell stage
DJ rearrangement first, and then V to DJ rearrangement.
Heptamer and nonamer sequence where RAG-1 and RAG-2 bind?
RSS (Recombination signaling sequence)
Location where adaptive immunity is activated
Lymph nodes/Spleen (secondary lymphoid organs)
Intracellular pattern recognition receptor that recognizes viral RNA
(MDA-5, RIG-I, DAI) Activate transcription of interferons
Expression of this cell surface molecule ensures progression past the first checkpoint
What is the pre-BCR receptor
This arm of the immune response is evolutionarily conserved
The innate immune system
B Cells develop in this central lymphoid organ
Signaling through the Pre-B cell receptor induces these downstream events
light chain rearrangement, allelic exclusion (inhibition of heavy chain rearrangement), shutting off of surrogate light chains, cell proliferation. BTK induction
What makes of the surrogate light chain?
lambda 5, V pre-B
This cytokine has systemic effects on the liver, inducing acute phase proteins
What are the three pro-inflammatory cytokines
IL-1, IL-6, and TNF
Cytokine that is most important for inducing vascular permeability
What condition is TNF associated with.
Chemokine that induces neutrophil migration into tissue
CXCL1 and (CXCL8 THIS IS THE MAJOR ONE)
Mixed Leukocyte recruitment
T Cell and dendritic cell migration into parafollicular zones
This enzyme is lymphocyte specific and catalyzes the VDJ recombination event
VDJ Recombinase (RAG-1/2); binds to RSS; TdT adds nucleotides, once RSS is clipped
Ubiquitous enzymes in VDJ recombination
DNA-PK, Artemis, Ku70 & 80, DNA ligase,
Type of pathogen generally recognized by cell surface PRRs
Bacterial; LPS TLRs 1,2,4,5,6
LPS triggers this PRR in macrophages, leading to cytokine synthesis