Immunology Jeopardy Flashcards Preview

Medical Immunology Bios 443/843 > Immunology Jeopardy > Flashcards

Flashcards in Immunology Jeopardy Deck (33):
1

This is produced by bone marrow stromal cells to induce development and proliferation of B lineage.

IL-7

2

This cell comes from a common lymphoid progenitor but is considered part of the innate immune response

NK cells/ ILCs

3

This cytosolic PRR cleaves IL-1 beta

The inflammasome NOD- Like receptors

4

The first cell that enters an inflamed tissue from the blood

Tissue macrophages are there first, but the first cell that comes from the blood stream are neutrophils, monocytes come after neutrophils and are more numerous when they respond.

5

The observation that a single antigen specific lymphocyte can undergo massive expansion/proliferation when binding specific antigen is a major tenent of the...

clonal expansion theory; (other tenets, non-reactivity to self, identical to parent cells, specific receptors

6

The most variable portion of the heavy and light chains are in this area of the amino acid sequence

What is the hyper variable region/CDR3

7

Viruses tend to induce the production of __________ after PRR engagement

Type I interferons ( include alpha and beta)

8

This molecule is an important opsonin in the innate immune response

Mannose binding lectin

9

What is an endocytic receptor?

Macrophage mannose receptor

10

What is a type of signaling receptors?

TLRs

11

What are some examples of cytosolic receptors?

RIG-1, NOD like receptor, MDA-5,

12

___________ and __________ are adhesion molecules that participate in in tight binding of neutrophils to endothelium

LFA-1 (Neutrophil) ICAM-1 (Endothelium)

13

This process occurs in the heavy chain locus during the Pro-B cell stage

DJ rearrangement first, and then V to DJ rearrangement.

14

Heptamer and nonamer sequence where RAG-1 and RAG-2 bind?

RSS (Recombination signaling sequence)

15

Location where adaptive immunity is activated

Lymph nodes/Spleen (secondary lymphoid organs)

16

Intracellular pattern recognition receptor that recognizes viral RNA

(MDA-5, RIG-I, DAI) Activate transcription of interferons

17

Expression of this cell surface molecule ensures progression past the first checkpoint

What is the pre-BCR receptor

18

This arm of the immune response is evolutionarily conserved

The innate immune system

19

B Cells develop in this central lymphoid organ

Bone Marrow

20

Signaling through the Pre-B cell receptor induces these downstream events

light chain rearrangement, allelic exclusion (inhibition of heavy chain rearrangement), shutting off of surrogate light chains, cell proliferation. BTK induction

21

What makes of the surrogate light chain?

lambda 5, V pre-B

22

This cytokine has systemic effects on the liver, inducing acute phase proteins

IL-6

23

What are the three pro-inflammatory cytokines

IL-1, IL-6, and TNF

24

Cytokine that is most important for inducing vascular permeability

TNF

25

What condition is TNF associated with.

Septic shock.

26

Chemokine that induces neutrophil migration into tissue

CXCL1 and (CXCL8 THIS IS THE MAJOR ONE)

27

CCL5

Mixed Leukocyte recruitment

28

CCL19

T Cell and dendritic cell migration into parafollicular zones

29

This enzyme is lymphocyte specific and catalyzes the VDJ recombination event

VDJ Recombinase (RAG-1/2); binds to RSS; TdT adds nucleotides, once RSS is clipped

30

Ubiquitous enzymes in VDJ recombination

DNA-PK, Artemis, Ku70 & 80, DNA ligase,

31

Type of pathogen generally recognized by cell surface PRRs

Bacterial; LPS TLRs 1,2,4,5,6

32

LPS triggers this PRR in macrophages, leading to cytokine synthesis

CD14, TLR4

33

B Cell receptor and antibodies are made up of these chains

heavy and light

Decks in Medical Immunology Bios 443/843 Class (56):