Immunology Lecture 12. Flashcards Preview

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Flashcards in Immunology Lecture 12. Deck (26):
1

What is the primary local immune response?

IgA

2

What is the primary serum antibody response?

IgG

3

How are microorganisms destroyed?

phagocytic cell

4

What type of cell is killed by a cytotoxic t cell?

infected host cells

5

What are the 6 types of innate immunity?

skin, pH barrier, flushing (ciliary action/flushing urinary tract), lysozyme (tears, nasal secretions, saliva), phagocytes, complement (lead to opsonization/lysis)

6

What is the primary adaptive immune response to bacteria?

antibody

7

How does strep. pneumonia evade immune response?

presence of antiphagocytic capsule

8

How does staph. aureus evade immune response?

has protein A which binds and blocks the opsonizing actin of IgG

9

How does salmonella typhus evade immunes response?

has ability to survive acid environment of the stomach

10

How does antibody protect the host?

prevents attachment to epithelium (IgA); triggers complement, binds to capsules acting as opsonin, neutralize toxins

11

How do we kill facultative intracellular parasites?

antibody won’t work - need activated macrophages (T-helper 1 response) = nonspecific response

12

What organisms can only be killed by the activated macrophage?

listeria monocytogenes (listeriosis), mycobacterium tuberculosis (TB), mycobacterium lepra (leprosy)

13

Why will the TH2 response not help with facultative intracellular parasites?

TH2 will help the organism get inside the cells where it will flourish

14

How is a macrophage activated?

by TH1 cell: CD40/CD40L and IFN-gamma

15

What is the TH1 response? What is released by TH1 cells?

cell mediated immunity: IL-2, IFN-y, TNF-a

16

What is the TH2 response? What is released by TH2 cells?

antibody production: IL4, IL5, IL-10, TGF-B

17

What is released by CD8 cells?

perforin, granzymes, granulysin

18

What does IL-2 do?

induces T-cell proliferation

19

What does TNF-a do?

activates endothelium to induce macrophage adhesion and exit blood vessel

20

What do CD40 and IFN-y do?

activate macrophage to destroy engulfed bacteria

21

What is the most importnat for clearance of parasites?

T cell response (activation of macrophages, CD8 cells), also eosinophils

22

What mechanisms do parasites use to escape the immune response?

inaccessibility (hide in host cell); avoidance of recognition (vary antigen expression, pick up host antigen); immunosuppression

23

How is antibody used in antiviral immunity?

neutralize the virus - binds to a portion of virus required for adsorption, penetration, uncoating, or replication

24

Which Ig is most important in antiviral immunity?

IgA - esp in respiratory, GI, genitourinary (local response)

25

What is the issue with antibody vaccines?

antibody prevents viral infection but once a virus infects a cell, antibody can’t kill the virus - need cell mediated cytotoxicity ONLY PREVENT

26

IL-2

drives proliferation and differentiation of virus specific T cells (comes from both CD8 and CD4)