Immunology of Interstitial Lung Disease, Michels, Lec Flashcards Preview

Year 2 Resp Exam 2 > Immunology of Interstitial Lung Disease, Michels, Lec > Flashcards

Flashcards in Immunology of Interstitial Lung Disease, Michels, Lec Deck (32):
1

What are the lung defenses of upper airways and bronchi

anatomic barriers, cough, mucociliary apparatus, airway epithelium
secretory IgA
dendritic cells, lymphocytes and Neutrophils

2

host defenses in alveolar spaces

alveolar macrophages
Ig, opsonins, surfactants
lymophocyte-mediated immunity
Neutrophils and eosinophils

3

What are the immune cells in pulmonary immune system

dendritic cells, alveolar macrophages
RBC,
lymph node dendritic cell
T cells, B cells, memory T cells
virus specific B cell

4

What is BALT and GALT

bronchial assoc lymphoid tissue
gut associate lymphoid tissue

5

what do macrophages look like in smoker lung

carbon in the macrophages

6

what does BAL look like in sarcoidosis

increased # lymphocytes, CD4 alveolitis

7

beaded looking cell sin BAL is indicative of what

asbestosis

8

Wha ttype cells will you see on BAL of scleroderma patient

neutrophils and eos

9

What type interstitial lung disease are corticosteroids not indicated

idiopathic pulmonary fibrosis

10

nonspecific interstitial pneumonia has good or poor response to corticosteroids

favorable

11

What events lead to development of interstitial pulmonary fibrosis

vasodialtion, coagulation, oxidative stress, vascualr remodeling
TGF-beta!!!! from alveolar macrophages
TNF alpha
PDGF

12

What is protective against radiation induced lung fibrosis

ACEI

13

what is evidence for cellular and humoral immunity in IPF

CD4 T cells
biased T cell R Vbeta
presence of autoAb in some studies
lymphoid neogenesis without organization

14

What are the genetic contributions for pulmonary fibrosis and lung cancer

defects in surfactant protein A2

15

genetic mutation related to familial interstitial ung disease

surfactant protein C gene

16

mutation in familities with idiopathic pulmonary fibrosis

telomerase mutations

17

mutation with pulmonary fibrosis

MUC58 promoter polymorphism

18

how does systemic sarcoidosis affect lungs

interstitial pneumonitis and granulmatous formation progress to fibrosis
damage alveolar and bronchial tissue and vascular surface area

19

What proteins are involved in inflammatory response in sarcoidosis

TNF alpha
IL7
MMP-12

20

what can cause progression to persistent granulmoatous inflammation

persitence of Ag
Failure of immune system to halt inflammatory processes

21

What is HS pneumonitis

group lung disease from inhalaltion of exogenous Ag molecules

22

Sx HS pneumonitis

transient fever, hypoxemia, myalgias, arthralgias, dyspnea, cough 2-9 hrs post exposure

23

Tx HS pnuemonitis

Sx resolve w/o Tx
take away exposure

24

What lymphocyte count suggests HS pneumonitis

>40% with higher perentage neutrophils and degranulated macrophages

25

What are the cell mediators in HS pneumonitis

TGF-b, IL-1 IL-12, TNF alpha
IL-2 IFN-y
IL-6 IL-17 IL-22

26

how can HS pneumonitis lead to fibrosis

genetic/environmental promoting factors that lead to alveolitis and then granulmatous inflammation leading to fibrosis

27

which T helper group is associated with chronic HS pnuemonitis vs acute

chronic TH2
acute TH1

28

what are the major contributors in eosinophilic lung disease

lipid mediators like PAF and Leukotrience C4
chemokines
cytokines
major basic protein

29

whic type eosinophlic lung disease can lead to respiratory failure

acute eosinophilic pneumonia

30

BAL finding acute eos pneumonia?
blood eos count?

eos
lymphocytes, neutrophils
notmal blood eos count

31

CXR acute eos pneumonia

kerly B lines
diffuse opacities

32

what can cause chronic eosinophilic pneumonia

idiopathic