Immunology Test II

Question 1

mechanism

inhibition of phagolysosome fusion

Answer 1

Mycobacteria

Question 2

mechanism

inhibition of antigen presentation: this microbe peptide interferes with TAP transporter

Answer 2

Herpes Simplex Virus (HSV)

Question 3

mechanism

inhibition of antigen presentation: inhibition of proteosomal activity; removal of class I MHC molecules from the ER

Answer 3

Cytomegalovirus (CMV)

Question 4

mechanism

inhibition of antigen presentation; inhibition of proteosomal activity

Answer 4

Epstein-Barr Virus (EBV)

Question 5

mechanism

production of IL-10, inhibition of macrophage and dendritic cell activation

Answer 5

Epstein-Barr Virus (EBV)

Question 6

mechanism

inhibition of effector cell activation; production of soluble cytokine receptors

Answer 6

Pox Virus

Question 7

this inhibits cell cycle progression

Answer 7

azathioprine

Question 8

inhibits calcineurin

Answer 8

cyclosporine

Question 9

block MHC-TCR signaling or deplete T cells en masse

Answer 9

anti-CD3 and anti-CD52

Question 10

prevent IL-2 signal transduction so no T cell growth

Answer 10

IL-2 receptor antibodies or antagonists

Question 11

blocks CD80/86 on APC so no costimulation during Ag presentation

Answer 11

CTLA-4-Ig

Question 12

various treatments (Humira, Adalimumab, Etnercept) that interferes with TNF-alpha

Answer 12

TNF-alpha