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Pathology > Immunopath > Flashcards

Immunopath Flashcards

1
Q

HLA allele for rheumatoid arthritis

A

DR4

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2
Q

HLA allele for Type 1 diabetes

A

DR3/DR4

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3
Q

HLA allele for ankylosing spondylitis

A

B27

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4
Q

HLA allele for postgonococcal arthritis

A

B27

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5
Q

Pt can’t bend spine at all. What HLA allele is affected?

A

B27 (ankylosing spondylitis)

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6
Q

HLA allele for autoimmune hepatitis

A

DR3

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7
Q

HLA allele for primary Sjogren syndrome

A

DR3

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8
Q

HLA for MS

A

DRB1*1501

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9
Q

HLA for SLE

A

DR3/DR2

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10
Q

HLA for celiac disease

A

DQ2/DQ3

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11
Q

HLA acute anterior uveitis

A

B27

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12
Q

Target Ag and sx in autoimmune hemolytic anemia

A

RBC membrane protein

Hemolysis and anemia

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13
Q

Ag and sx in autoimmune thrombocytopenia purpura

A

Platelet membrane protein (GpIIb-IIIa)

Bleeding

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14
Q

PTPN22

A

Rheumatoid Arthritis

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15
Q

NOD2

A

Crohn’s disease

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16
Q

Neisseria infections associated with what defect

A

MAC (membrane attack complex)(C5b-C9)

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17
Q

Autoimmune Hemolytic Anemia

A

Ag = RBC membrane protein
Mech - opsonization and phagocytosis of red cells
Sx = hemolysis, anemia

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18
Q

Autoimmune thrombocytopenic purpura

A

platelet membrane proteins (GpIIbIIIa)
oponiszation and phagocytosis of platelets
bleeding

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19
Q

Vasculitits cuased by ANCA

A

ANCA = anti-neutrophil cytoplasmic antbodies
neutorphil granule protiens
vasculitis

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20
Q

Goodpasture Syndrome

A

lung and kidney
basement membrane of kidney glomeruli and lung alevoli
nephritis; lung hemorrhage

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21
Q

Acute Rheumatic Fever

A

streptococcal cell wall antigen
inflammation and macrophage activation
myocarditis; arthritis

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22
Q

Myasthenia gravis

A

acetylcholine receptor
ab inhibits Ach binding
muscle weakness; paralysis

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23
Q

Graves disease

A

TSH receptor
Ab mediated stimulation of TSH receptors
hyperthyroidism

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24
Q

Insulin resistant diabetes

A

insulin receptor targeted (pancreatic beta cells)
Ab inhibits binding of insulin
hyperglycemia, ketoacidosis

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25
Q

anti-basement membrane antibodies

A

Goodpasture disease

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26
Q

autoantibodies to membrane glycoproteins

A

immunologic thrombocytopenic purpura

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27
Q

Hepatitis B virus antigens and rash

A

Polyarteritis nodosa

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28
Q

PAS stain

A

basement membranes

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29
Q

lumpy fluorescence staining, smoky urine, red cell casts

A

Acute Proliferative Glomerulonephritis

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30
Q

Citrullinated self proteins

A

Rheumatoid arthritis

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31
Q

myelin basic protein

A

MS

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32
Q

pancreatic islet beta cells

A

type 1 DM

33
Q

oligoclonoal immunoglobulin bands in CSF

A

MS

34
Q

antibodies to ganglioside

A

Guillain-Barre Syndrome

35
Q

Aschoff bodies

A

Rheumatic fever

36
Q

Speckled pattern

A

non specific

37
Q

centromeric pattern

A

CREST syndrome

38
Q

anti-double stranded DNA

A

SLE

39
Q

anti-Smith

A

SLE

40
Q

anti-histone

A

drug induced lupus

41
Q

DNA topoisomerase I

A

systemic sclerosis (scleroderma)

42
Q

Scl70

A

systemic sclerosis (scleroderma)

43
Q

anti-centromere

A

CREST syndrome

44
Q

SS-Ro and La

A

Sjogren

45
Q

Jo-1

A

Autoimmune myositis

46
Q

anti- SRP antibody

A

polymyositis

47
Q

positive Schirmer test, anti Ro and La, Sicca syndrome, Mikulicz syndrome

A

Sjogren

48
Q

helicotropic rash, anti-Jo-1

A

dermatomyositis

49
Q

what type of cell involved with bacteria and fungus

A

neutrophils

50
Q

what type of cells with viruses

A

lymphocytes

51
Q

C1 inhibitor problem

A

hereditary angioedema

52
Q

Neisseria infections

A

problem with MAC

53
Q

C3 problem

A

infections; immune complex mediated glomerulonephritis

54
Q

Adenosine deaminase (ADA) deficiency

A

SCID

55
Q

male pt, recurrent infections (giardia), no IgA

A

Bruton Disease (X linked agammaglobulinemia) (brutan tyrosine kinase mutation)

56
Q

abnormal 22q11

A

DiGeorge Syndrome

57
Q

CD40L genetic defect

A

Hyper-IgM syndrome

58
Q

recurrent herpes infections

A

common variable immunodeficiency

- can lead to lymphoid and gastric malignancies

59
Q

sinopulmonary infections, diarrhea from intestinal infections, lack of terminal differentitaiton

A

Isolated IgA deficiency

60
Q

pregnant woman with HTN and proteinuria and elevated liver enzymes

A

HELLP syndrome

61
Q

petechia, epistaxis, chx infections

A

WASP mutation

Wiskit-Aldrich syndrome

62
Q

abnormal ATM gene

A

Ataxia telangiectasia

63
Q

disease associated with breast and hematopoetic malignancies

A

Ataxia telangiectasia

64
Q

CCR5 defect

A

makes you immune to HIV

65
Q

fever, wt loss, diarrhea, generalized lymphadenopathy, multiple infections, neuro disease, secondary neoplasms

A

AIDS

66
Q

human herpes virus 8

A

Kaposi sarcoma (AIDS)

67
Q

EBV

A

Burkitt lymphoma
immunodeficiency-associated large B cell lymphoma
Primary CNS lymphoma

68
Q

clonal proliferations + DNA glitches

A

B cell lymphoma

69
Q

HPV 16, 18

A

cervical cancer/dysplasia

70
Q

HPV

A

squamous cell carincoma of the anus and vulva

71
Q

congo red stain

A

amyloid

72
Q

apple green birefringence on polarizing

A

amyloid

73
Q

AL

A

multiple myeloma

plasmocytoma

74
Q

AA

A

RA

chronic infection

75
Q

A beta

A

Alzheimer plaques

76
Q

B2 microglobulin build up

A

chronic renal failure

77
Q

transthyretin

A

systemic senile amyloidosis

78
Q

calcitonin deposits

A

medullary carincoma of thyroid

Pathology (5 decks)

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