Immunoproliferative disorders

Question 1

what are monoclonal gamopathies

Answer 1

conditions characterised by abmormal proliferation of single clone of plasma cells = production of M protein

Question 2

3 monoclonal gammopathies which are immunoproliferative disorders (abnormal proliferation of lymphoid/plasma cells)

Answer 2

multiple myeloma

waldenstrom’s macroglobulinemia

monoclonal gammopathy of undetermined significance (MGUS)

heavy chain disease

Question 3

what is MGUS

Answer 3

premalignant condition - presence of m protein in blood without symptoms or organ damage

Question 4

what is multiple myeloma characterised by

Answer 4

abnormal proliferation of plasma cells in bone marrow = m protein production

Question 5

what in the bone is common in MM

Answer 5

osteolytic bone lesions (bone breakdown)

Question 6

what is calcium like in MM

Answer 6

high (hypercalcaemia) due to bone loss

Question 7

What antibodies are overproduced by B lymphocytes in waldenstrom’s macroglobulinemia leading to blood thickening and damage to kidneys

Answer 7

IgM

Question 8

what is alpha heavy chain disease characterised by

Answer 8

overproduction of abnormal alpha heavy chains by plasma cells which accumulate in small intestine