Immunosuppressants Flashcards Preview

Pharm Midterm 2 > Immunosuppressants > Flashcards

Flashcards in Immunosuppressants Deck (41):
1

What are the T-cell inhibitors

Cyclosporine
Tacrolimus
Sirolimus

2

What is the Glucocorticoid

Prednisone

3

What are the Cytotoxic drugs

Mycophenolate mofetil
Cyclophosphamide
Azathioprine
MTX

4

What are the Immunosuppresive Abs

Muromonab
Daclizumab
Basiliximab
Antithymocyte globulin
RhoD Immunoglobulin

5

How do T-cell inhibitors work

Immunophilin ligands
Prevent activation, differentiation and cytokine release

6

What is Cyclosporine's MOA

Bind cyclophilin and inhibit calcineurin
Decreased cytokine production

7

How does grapefruit juice increase the absorption of Cyclosporine

Inhibit P-glycoprotein

8

What metabolizes Cyclosporine

3A4

9

What does Cyclosporine interact with

Aminoglycosides (Amikacin)
Spironolactone

10

What are the main Cyclosporine AE

Gum hyperplasia
Hirsuitism

11

What are the other Cyclosporine AE

Nephrotoxicity
Hyperkalemia
Increased Lymphoma risk

12

Which T-cell inhibitor is a macrolide, 100x more potent than Cyclosporine

Tacrolimus

13

How does Tacrolimus act

Bind FK-506 inhibiting calcineurin

14

What does Tacrolimus absorption depend on

Bile

15

What is the main Tacrolimus AE

Neurologic effects

16

Does Tacrolimus cause gum hyperplasia and hirsutism

No

17

How does Sirolimus act

Inhibit mTOR and IL-2 action

18

What is Sirolimus used for

Prevent re-stenosis after angioplasty

19

What happens if you combine Sirolimus with Cyclosporine

Nephrotoxicity

20

What is the Sirolimus AE

Hyperlipidemia

21

How does Prednisone act

Inhibit cell cycle
Induce apoptosis in activated T-cells
Decrease cellular and humoral response

22

What are the Prednisone AE

Adrenal suppression, Cushing features
Ostoporosis
HTN, Peptic ulcer, Muscle wasting

23

What does Mycophenolate mofetil do

Inhibit IMP dehydrogenase
Blocks PURINE synthesis
Suppress B and T cell activation

24

What are the Mycophenolate mofetil AE

Diarrhea
Myelosuppression (neutropenia)

25

What is Azathioprine used for

Renal transplant
Autoimmune disease

26

What is Azathioprine converted to

6-MP

27

How does Allopurinol affect Azathioprine

Increases its concentration by inhibiting Xanthine oxidase

28

What is the Alkylating agent

Cyclophosphamide

29

What is Cyclophosphamide used for

Wegener's
SLE
Autoimmune

30

What are the Cyclophosphamide AE

Hemorrhagic Cystitis
BM suppression

31

Tx for Cyclophosphamide Hemorrhagic Cystitis

Mesna

32

What is useful in RA

MTX

33

How does MTX act

Inhibit AICAR transformylase

34

What are the MTX AE

BM suppression
Mucositis
Hepatic fibrosis

35

What is the Anti-CD3 Ab

Muromonab

36

What is Muromonab used for

Acute graft rejection

37

What does Muromonab kill

T-cells

38

What are the Muromonab AE

HS

39

IL-2r antagonist used pre-op for transplantation

Daclizumab
Basiliximab

40

Human IgG Ab against Rh Ag

RhoD Immunoglobulin

41

What is RhoD Immunoglobulin used for

Prevent hemolytic disease of the newborn