immunosuppressants

Question 1

cyclosporine MOA?

Answer 1

calcineurin inhibitor, binds cyclophilin

prevents IL2 transcription

Question 2

cyclosporine use?

Answer 2

txp rejection ppx
psoriasis
RA

Question 3

cyclosporine toxicity?

Answer 3

NEPHROTOXIC
HTN
hyperlipidemia
neurotoxicity

** gingival hyperplasia, hirsutism

Question 4

tacrolimus MOA?

Answer 4

calcineurin inhibitor, binds FKBP

prevents IL2 transcription

Question 5

tac use?

Answer 5

txp rejection ppx

Question 6

tac toxicity?

Answer 6

like cyclosporine but w/o gingival hyperplasia/hirsutism

** increased risk of diabetes and neurotoxicity

Question 7

sirolimus (rapamycin) MOA?

Answer 7

mTOR inhibitor

prevents response to IL2

Question 8

sirolimus use?

Answer 8

kidney txp rejection ppx

synergistic with cyclosporine

Question 9

sirolimus toxicity?

Answer 9

anemia
TCP
leukopenia
insulin resistance
hyperlipidemia

Question 10

daclizumab, basiliximab?

Answer 10

monoclonal Abs that block IL2R

Question 11

azathioprine MOA?

Answer 11

6MP precursor, blocks nucleotide synthesis

Question 12

azathioprine use?

Answer 12

txp rejection ppx
RA
Crohn
glomerulonephritis
autoimmune

Question 13

azathioprine toxicity?

Answer 13

leukopenia
anemia
TCP

** toxicity increased by allopurinol

Question 14

glucocorticoid MOA?

Answer 14

inhibit NFKB - decreases transcription of many cytokines

Question 15

aldesleukin?

Answer 15

IL 2
used in renal cell carcinoma
metastatic melanoma

Question 16

filgrastim

Answer 16

G-CSF

Question 17

sargramostim

Answer 17

GM-CSF

Question 18

romiplostim, eltrombopag

Answer 18

used in TCP

Question 19

oprelvekin

Answer 19

IL 11

used in TCP

Question 20

alemtuzumab?

Answer 20

–>CD52

used in CLL

Question 21

bevacizumab?

Answer 21

–>VEGF

used in CRC, renal cell carcinoma

Question 22

cetuximab?

Answer 22

–> EGFR

used in stage IV CRC, head/neck ca

Question 23

rituximab?

Answer 23

–> CD20

used in BCell NHL, CLL, RA, ITP

Question 24

trastuzumab?

Answer 24

–>HER2neu

used in brca

Question 25

adalimumab, infliximab?

Answer 25

-->TNF-a | used in IBD, RA, ankylosing spondylitis, psoriasis

Question 26

eculizumab?

Answer 26

-->C5 (complement) | used in PNH

Question 27

natalizumab?

Answer 27

-->alpha 4 integrin used in MS, Crohn ** risk of PML in pts with JC virus

Question 28

abciximab?

Answer 28

--> IIb/IIIa | used in patients getting PCI

Question 29

denosumab?

Answer 29

--> RANKL | used in osteoporosis

Question 30

digoxin immune Fab?

Answer 30

antidote for dig toxicity

Question 31

palivizumab?

Answer 31

--> RSV F protein | used for RXV ppx in high risk infants

Question 32

ranibizumab?

Answer 32

--> VEGF | used in neovascular macular degeneration