Immunosuppressants

Question 1

Calcineurin Inhibitor used for transplant rejection prophylaxis, psoriasis, RA

Answer 1

Cyclosporine

Question 2

Toxicity for Cyclosporine

Answer 2

Nephrotoxicity, HTN, hyperlipidemia, hyperglycemia, tremor, hirsutism, gingival hyperplasia

Question 3

MoA Cyclosporine

Answer 3

Calcineurin inhibitor that binds cyclophilin. Blocks T cell activation by preventing IL-2 transcription

Question 4

Calcineurin inhibitor that binds FK506 binding protein, Blocks T cell activation by preventing IL-2 transcription.

Answer 4

Tacrolimus (for transplant rejection prophylaxis)

Question 5

S/E of Tacrolimus

Answer 5

icnrease risk for diabetes and neurotoxicity

Question 6

mTOR inhibitor that binds to FKBP

Answer 6

Sirolimus (Rapamycin) - prevents IL-2 signal transduction

Question 7

Non-nephrotoxic -limus so use for Kidney transplant

Answer 7

Sirolimus

Question 8

Mab that blocks IL-2R

Answer 8

Basiliximab

Question 9

Antimetabolite precursor of 6-mercaptopurine. Inhibits lymphocyte proliferation by blocking nucleotide synthesis

Answer 9

Azathioprine

Question 10

Used for RA, Crohn’s, transplant prophylaxis, glomerulonephritis

Answer 10

Azathioprine

Question 11

Inhibit NF-KB

Suppressboth B and T cell fx by decreasing transcription of many cytokines

Answer 11

Glucocorticosteroids

Question 12

S/E of Glucocorticosteroids

Answer 12

Hyperglycemia, osteoporosis, Central Obesity, Muscle breakdown, pyschosis, acne, HTN, cataracts, peptic ulcers

Question 13

Epoetin alfa (erythropoietin)

Answer 13

Use for anemias (esp in renal failure)

Question 14

Thrombopoietin

Answer 14

Used for thrombocytopenia

Question 15

Oprelvekin

Answer 15

IL-11, used for thrombocytopenias

Question 16

Filgrastim

Answer 16

GCS-F, used to recovery of bone marrow

Question 17

Sargramostim

Answer 17

GMC-SF, Recovery of Bone Marrow

Question 18

Aldesleukin

Answer 18

IL-2, used for Renal cell carcinoma, metastatic melanoma

Question 19

Clinical use for IFN-alpha

Answer 19

Chronic hepB and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma

Question 20

Clinical use for IFN-beta

Answer 20

Multiple Sclerosis

Question 21

Clinical use for IFN-gamma

Answer 21

Chronic Granulomatous Disease

Question 22

Targets CD52, used for CLL

Answer 22

Alemtuzumab

Question 23

Targets VEGF, used for colorectal CA, Renal cell carcinoma

Answer 23

Bevacizumab

Question 24

Targets EGFR, used for Stage IV colorectal cancer

Answer 24

Cetuximab

Question 25

Targets HER2/neu - Breast CA, Gastric Cancer

Answer 25

Trastuzumab

Question 26

Targets TNF-alpha - Used for IBD, RA, ankylosing spondylitis, psoriasis

Answer 26

Infliximab, adalimumab

Question 27

targets alpha4-integrin

Answer 27

Natalizumab

Question 28

Drug that increases risk of PML in patients with JC virus

Answer 28

Natalizumab

Question 29

Drug for give in patients undergoing percutaneous coronary intervention

Answer 29

Abciximab

Question 30

Target for Abciximab

Answer 30

Glycoprotein IIb/IIIa

Question 31

Targets RANKL

Answer 31

Denosumab

Question 32

Clinical use for Denosumab

Answer 32

osteoporosis; inhibits osteoclast maturation (mimics osteoprotegrin)

Question 33

Antidote for digoxin toxicity

Answer 33

digoxin immune Fab

Question 34

Drug that targets IgE, used for allergic asthma

Answer 34

Omalizumab

Question 35

MoA of Omalizumab

Answer 35

Prevents IgE binding to FceRI

Question 36

Used for RSV prophylaxis in high risk infants (like pre-mature)

Answer 36

Palivizumab - binds F protein

Question 37

What did the fox say?

Answer 37

who the fuck cares