Immunosuppressants Flashcards Preview

STEP 1 Pharm > Immunosuppressants > Flashcards

Flashcards in Immunosuppressants Deck (23):
1

Cyclosporine

Calcineurin inhibitor that binds cyclophilin. Blocks dephosphorylation of NFAT-P. Without this, no NFAT binding and transcription of IL-2. No T-cell activation

Use for transplant rejection prophylaxis, psoriasis, and RA

2

Cyclosporine Toxicity

VERY nephrotoxic.

Also can cause HTN, tremor, gingival hyperplasia.

3

Tacrolimus

Calcineurin Inhibitor that binds FKBP. Prevents NFAT from transcribing IL-2. No T cell activation.

Used to prevent organ transplant rejction

4

Tacrolimus toxicity

NEPHROTOXIC.

Increased risk of diabetes and neurotoxicity. No gingival hyperplasia.

5

Sirolimus/rapamycin

Blocks M-TOR which transduces signal of IL2 activation. Prevents T cell activation and B-cell differentiation.

6

Sirolimus/rapamycin

Blocks M-TOR by binding FKBP which transduces signal of IL2 activation. Prevents T cell activation and B-cell differentiation.

Used for prevention of kidney transplant rejection

7

Sirolimus toxicity

NOT nephrotoxic, but can cause pancytopenia.

8

Basiliximab

Monoclonal antibody that blocks IL2R.

Used in kidney transplant rejection prophylaxis.

9

Basiliximab toxicity

Edema, hypertension, tremor

10

Azathioprine

Precursor to 6MP. Purine analog that prevents de novo purine synthesis.

Use in transplant rejection, RA, Crohns. Don't use with allopurinol.

11

Glucocorticoids

Block NFkB which decreases B and T cell function.

Used to prevent transplant rejection.

12

Oprelvekin

Recombinant IL11 used in thrombocytopenia.

13

Alemtuzumab

CD52 MAb used for CLL.

14

Bevacizumab

VEGF MAb used for colorectal cancer and renal cell carcinoma

15

Cetuximab

EGFR monoclonal antibody. Stage IV colorectal cancer

16

Rituximab

CD20 MAb used in B-cell NHL, RA, ITP

17

Rituximab

CD20 MAb used in B-cell NHL, RA, ITP

18

Trastuzumab

AntiHer2 used in breast cancer/ gastric cancer

19

Infliximab/adalimumab

TNFalpha MAb

20

Natalizumab

Alpha 4 integrin MAb used for MS. Can cause PML with JC virus.

21

Denosumab

RANK L antibody. Prevents osteoblast maturation. Mimics osteoprotegerin.

22

Omalizumab

Binds IgE prevents asthma

23

Palivizumab

RSV F protein monoclonal antibody. Prophylaxis in high risk infants.