Flashcards in Immunosuppressants For Autoimmune Diseases Deck (13):
Examples of TNF-a inhibitors
Which TNFa has less immunogenicity than the others? (A good thing)
Etanercept MOA, AE
MOA: fusion protein, fuses TNF Receptor and Fc on IgG
Use: rheumatic syndromes
AE: activation of TB, inc infections and lymphoma in kids
Infliximab use, MOA, AE
MOA: MAB that neutralizes TNFa
AE: latent TB, infxn, lymphoma
Give with MTX to prevent ab formation
MOA: MAB against TNFa
AE: TB, infxn, basal/squamous CC
Which drug is a IL-6 neutralizer?
Toclizumab use, MOA, AE
Use: RA unresponsive to TNFa
MOA: blocks IL6/JAKSTAT
AE: TB, infection, GI perforation, can lead to CYP inductions
Which drugs are B cell depletors?
Rituximab use, MOA, AE
use: refractory RA, Hodgkins, CLL
MOA: MAB against CD20
AE: hep B reactivation, viral infants, fetus probs
Which two immunosuppressants do not inc risk of TB activation?
Drugs that interfere with co-stimulation?
Abatacept use, MOA, AE
Use: refract RA
MOA: fusion protein that neutralizes CD80/86 on antigen presenting cells
AE: infxn, lung cancer, lymphoma