Immunosuppressants For Autoimmune Diseases Flashcards Preview

Spring Pharm 3 > Immunosuppressants For Autoimmune Diseases > Flashcards

Flashcards in Immunosuppressants For Autoimmune Diseases Deck (13):
1

Examples of TNF-a inhibitors

Etanercept
Infliximab
Adalimumab

2

Which TNFa has less immunogenicity than the others? (A good thing)

Etanercept

3

Etanercept MOA, AE

MOA: fusion protein, fuses TNF Receptor and Fc on IgG
Use: rheumatic syndromes
AE: activation of TB, inc infections and lymphoma in kids

4

Infliximab use, MOA, AE

Use: IBD
MOA: MAB that neutralizes TNFa
AE: latent TB, infxn, lymphoma
Give with MTX to prevent ab formation

5

Adalimumab

MOA: MAB against TNFa
AE: TB, infxn, basal/squamous CC

6

Which drug is a IL-6 neutralizer?

Tocilizumab

7

Toclizumab use, MOA, AE

Use: RA unresponsive to TNFa
MOA: blocks IL6/JAKSTAT
AE: TB, infection, GI perforation, can lead to CYP inductions

8

Which drugs are B cell depletors?

Rituximab

9

Rituximab use, MOA, AE

use: refractory RA, Hodgkins, CLL
MOA: MAB against CD20
AE: hep B reactivation, viral infants, fetus probs

10

Which two immunosuppressants do not inc risk of TB activation?

Rituximab
Abatacept

11

Drugs that interfere with co-stimulation?

Abatacept

12

Abatacept use, MOA, AE

Use: refract RA
MOA: fusion protein that neutralizes CD80/86 on antigen presenting cells
AE: infxn, lung cancer, lymphoma

13

Fxns of TNFa

Inc adhesion molecule expression on endothelial
Inc matrix metallopoteases released by fibroblasts
Inc chemokines released by macrophages