Immunotherapies Flashcards

1
Q

Ipilimumab(Yervoy®)

A

Ipilimumab(Yervoy®)

  • Mechanism of action: blocks the Cytotoxic T-Cell Lymphocyte associated Antigen (CTLA-4) inhibitory signal, and allows the CTLs to destroy the cancer cells
  • Indicated for treatment of melanoma
  • Side effects are immunological-related: rash, diarrhea, thyroid
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2
Q

Anti-Programmed Cell Death-1 (PD-1)

A

Anti-Programmed Cell Death-1 (PD-1)
- PD-1 (Programmed Cell Death) is an inhibitory signaling receptor expressed on activated T cells, enhance the ability of T cells to kill tumor

Drugs:

  • Pembrolizumab(Keytruda®), Nivolumab(Opdivo®) –PD-1 inhibitor
  • Atezolizumab(Tecentriq®), Avelumab(Bavencio®) –PD-L1 inhibitor
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3
Q

Pembrolizumab(Keytruda®),

A

PD-1 inhibitor

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4
Q

Nivolumab(Opdivo®) –

A

PD-1 inhibitor

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5
Q

Atezolizumab(Tecentriq®),

A

PD-L1 inhibitor

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6
Q

Avelumab(Bavencio®) –

A

PD-L1 inhibitor

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7
Q

Immune-related adverse event for immunotherapy

A

Immune-related adverse event for immunotherapy

  • Colitis
  • Hypophysitis
  • Arthritis
  • Dermatitis
  • Adrenal insufficiency
  • Rash
  • Hepatitis
  • Motor and sensory neuropathies
  • Pneumonitis 
  • Thyroiditis
  • Pancreatitis
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